Plexin A1

Plexin-A1 is a protein that in humans is encoded by the PLXNA1 gene.[5][6]

PLXNA1
Identifiers
Aliases	PLXNA1, NOV, NOVP, PLEXIN-A1, PLXN1, Plexin A1
External IDs	OMIM: 601055 MGI: 107685 HomoloGene: 56426 GeneCards: PLXNA1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.3 Start 126,988,594 bp[1] End 127,037,392 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 89,316,314 bp[2] End 89,362,620 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • semaphorin receptor activity • receptor activity • signaling receptor activity Cellular component • integral component of membrane • membrane • cell membrane • semaphorin receptor complex • extracellular exosome • integral component of plasma membrane Biological process • regulation of axon extension involved in axon guidance • neuron projection extension • multicellular organism development • neuron projection guidance • branchiomotor neuron axon guidance • dichotomous subdivision of terminal units involved in salivary gland branching • regulation of smooth muscle cell migration • semaphorin-plexin signaling pathway • signal transduction • negative regulation of cell adhesion • regulation of cell shape • regulation of cell migration • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • positive regulation of axonogenesis • semaphorin-plexin signaling pathway involved in axon guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5361	18844
Ensembl	ENSG00000114554	ENSMUSG00000030084
UniProt	Q9UIW2	P70206
RefSeq (mRNA)	NM_032242	NM_008881
RefSeq (protein)	NP_115618	NP_032907
Location (UCSC)	Chr 3: 126.99 – 127.04 Mb	Chr 6: 89.32 – 89.36 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Plexin A1 has been shown to interact with AKT1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000114554 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030084 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci U S A. 93 (2): 674–8. Bibcode:1996PNAS...93..674M. doi:10.1073/pnas.93.2.674. PMC 40111. PMID 8570614.
6. "Entrez Gene: PLXNA1 plexin A1".
7. Turner, Laura J; Nicholls Sarah; Hall Alan (Aug 2004). "The activity of the plexin-A1 receptor is regulated by Rac". J. Biol. Chem. United States. 279 (32): 33199–205. doi:10.1074/jbc.M402943200. ISSN 0021-9258. PMID 15187088.

Further reading

• Takahashi T, Fournier A, Nakamura F, et al. (1999). "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors". Cell. 99 (1): 59–69. doi:10.1016/S0092-8674(00)80062-8. PMID 10520994.
• Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
• Rohm B, Rahim B, Kleiber B, et al. (2001). "The semaphorin 3A receptor may directly regulate the activity of small GTPases". FEBS Lett. 486 (1): 68–72. doi:10.1016/S0014-5793(00)02240-7. PMID 11108845.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Takahashi T, Strittmatter SM (2001). "Plexina1 autoinhibition by the plexin sema domain". Neuron. 29 (2): 429–39. doi:10.1016/S0896-6273(01)00216-1. PMID 11239433.
• Zanata SM, Hovatta I, Rohm B, Püschel AW (2002). "Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse". J. Neurosci. 22 (2): 471–7. doi:10.1523/JNEUROSCI.22-02-00471.2002. PMC 6758682. PMID 11784792.
• Mitsui N, Inatome R, Takahashi S, et al. (2002). "Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling". EMBO J. 21 (13): 3274–85. doi:10.1093/emboj/cdf328. PMC 125392. PMID 12093729.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Usui H, Taniguchi M, Yokomizo T, Shimizu T (2003). "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains". Biochem. Biophys. Res. Commun. 300 (4): 927–31. doi:10.1016/S0006-291X(02)02966-2. PMID 12559962.
• Bachelder RE, Lipscomb EA, Lin X, et al. (2003). "Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells". Cancer Res. 63 (17): 5230–3. PMID 14500350.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Toyofuku T, Zhang H, Kumanogoh A, et al. (2004). "Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2". Genes Dev. 18 (4): 435–47. doi:10.1101/gad.1167304. PMC 359397. PMID 14977921.
• Turner LJ, Nicholls S, Hall A (2004). "The activity of the plexin-A1 receptor is regulated by Rac". J. Biol. Chem. 279 (32): 33199–205. doi:10.1074/jbc.M402943200. PMID 15187088.
• Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. Bibcode:2006Natur.440.1194M. doi:10.1038/nature04728. PMID 16641997.