PLEKHB2

Pleckstrin homology domain-containing family B member 2 is a protein that in humans is encoded by the PLEKHB2 gene.[5][6]

PLEKHB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3AJ4, 3VIA
Identifiers
Aliases	PLEKHB2, EVT2, pleckstrin homology domain containing B2
External IDs	OMIM: 618452 MGI: 2385825 HomoloGene: 9938 GeneCards: PLEKHB2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q21.1 Start 131,104,847 bp[1] End 131,353,709 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 B Start 34,849,976 bp[2] End 34,879,580 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • phosphatidylinositol-3,4,5-trisphosphate binding Cellular component • membrane • recycling endosome membrane • endosome • integral component of membrane Biological process • regulation of cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55041	226971
Ensembl	ENSG00000115762	ENSMUSG00000026123
UniProt	Q96CS7	Q9QZC7
RefSeq (mRNA)	NM_001031706 NM_001100623 NM_001267062 NM_001267063 NM_001267064 NM_001267065 NM_001267066 NM_001267067 NM_001267068 NM_001309448 NM_001309450 NM_001309451 NM_001309452 NM_017958	NM_145516 NM_175421 NM_001357425
RefSeq (protein)	NP_001094093 NP_001253991 NP_001253992 NP_001253993 NP_001253994 NP_001253995 NP_001253996 NP_001253997 NP_001296377 NP_001296379 NP_001296380 NP_001296381 NP_060428 NP_001094093.1	NP_663491 NP_780630 NP_001344354
Location (UCSC)	Chr 2: 131.1 – 131.35 Mb	Chr 1: 34.85 – 34.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000115762 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026123 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Krappa R, Nguyen A, Burrola P, Deretic D, Lemke G (May 1999). "Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes". Proc Natl Acad Sci U S A. 96 (8): 4633–8. doi:10.1073/pnas.96.8.4633. PMC 16384. PMID 10200314.
6. "Entrez Gene: PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Dowler S, Currie RA, Campbell DG, et al. (2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.