PLD5

Phospholipase D family, member 5 is a protein that in humans is encoded by the PLD5 gene.[5]

PLD5
Identifiers
AliasesPLD5, PLDC, phospholipase D family member 5
External IDsMGI: 2442056 HomoloGene: 16081 GeneCards: PLD5
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q43Start242,082,986 bp[1]
End242,524,697 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

200150

319455

Ensembl

ENSG00000180287

ENSMUSG00000055214

UniProt

Q8N7P1

Q3UNN8

RefSeq (mRNA)

NM_001195811
NM_001195812
NM_152666
NM_001320272
NM_001372062

RefSeq (protein)

NP_001182740
NP_001182741
NP_001307201
NP_001358991

Location (UCSC)Chr 1: 242.08 – 242.52 MbChr 1: 175.96 – 176.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

Model organisms have been used in the study of PLD5 function. A conditional knockout mouse line, called Pld5tm1a(KOMP)Wtsi[10][11] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[12][13][14]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8][15] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.[8]

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References
  1. GRCh38: Ensembl release 89: ENSG00000180287 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000055214 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: PLD5 phospholipase D family, member 5". Retrieved 2011-12-04.
  6. "Salmonella infection data for Pld5". Wellcome Trust Sanger Institute.
  7. "Citrobacter infection data for Pld5". Wellcome Trust Sanger Institute.
  8. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  9. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  10. "International Knockout Mouse Consortium".
  11. "Mouse Genome Informatics".
  12. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  13. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  14. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  15. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading


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