PLAGL1

Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.[5][6][7]

PLAGL1
Identifiers
Aliases	PLAGL1, LOT1, ZAC, ZAC1, PLAG1 like zinc finger 1
External IDs	OMIM: 603044 MGI: 1100874 HomoloGene: 31401 GeneCards: PLAGL1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q24.2 Start 143,940,300 bp[1] End 144,064,599 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 A2|10 4.72 cM Start 13,060,504 bp[2] End 13,131,694 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • nucleic acid binding • metal ion binding • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • Golgi apparatus • intracellular membrane-bounded organelle • cell nucleus • nucleoplasm • nuclear body Biological process • cell differentiation • regulation of transcription, DNA-templated • cell cycle arrest • positive regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • apoptotic process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • transcription from RNA polymerase II promoter • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5325	22634
Ensembl	ENSG00000118495	ENSMUSG00000019817
UniProt	Q9UM63	n/a
RefSeq (mRNA)	NM_006718 NM_001080951 NM_001080952 NM_001080953 NM_001080954 NM_001080955 NM_001080956 NM_001289037 NM_001289038 NM_001289039 NM_001289040 NM_001289041 NM_001289042 NM_001289043 NM_001289044 NM_001289045 NM_001289046 NM_001289047 NM_001289048 NM_001289049 NM_002656 NM_001317156 NM_001317157 NM_001317158 NM_001317159 NM_001317160 NM_001317161 NM_001317162	NM_009538
RefSeq (protein)	NP_001074420 NP_001074421 NP_001074422 NP_001074423 NP_001074424 NP_001074425 NP_001275966 NP_001275967 NP_001275968 NP_001275969 NP_001275970 NP_001275971 NP_001275972 NP_001275973 NP_001275974 NP_001275975 NP_001275976 NP_001275977 NP_001275978 NP_001304085 NP_001304086 NP_001304087 NP_001304088 NP_001304089 NP_001304090 NP_001304091 NP_006709	n/a
Location (UCSC)	Chr 6: 143.94 – 144.06 Mb	Chr 10: 13.06 – 13.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.[7]

Interactions

PLAGL1 has been shown to interact with P53.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000118495 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019817 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ (Oct 1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. doi:10.1074/jbc.273.36.23026. PMID 9722527.
6. Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L (Aug 1998). "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8835–40. doi:10.1073/pnas.95.15.8835. PMC 21163. PMID 9671765.
7. "Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1".
8. Huang SM, Schönthal AH, Stallcup MR (Apr 2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene. 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197.

Further reading

• Vernon M (2005). "Fifty years of research on the intelligence of deaf and hard-of-hearing children: a review of literature and discussion of implications". J Deaf Stud Deaf Educ. 10 (3): 225–31. doi:10.1093/deafed/eni024. PMID 15888725.
• Abdollahi A, Roberts D, Godwin AK, Schultz DC, Sonoda G, Testa JR, Hamilton TC (1997). "Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors". Oncogene. 14 (16): 1973–9. doi:10.1038/sj.onc.1201034. PMID 9150364.
• Abdollahi A, Godwin AK, Miller PD, Getts LA, Schultz DC, Taguchi T, Testa JR, Hamilton TC (1997). "Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells". Cancer Res. 57 (10): 2029–34. PMID 9158001.
• Spengler D, Villalba M, Hoffmann A, Pantaloni C, Houssami S, Bockaert J, Journot L (1997). "Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain". EMBO J. 16 (10): 2814–25. doi:10.1093/emboj/16.10.2814. PMC 1169890. PMID 9184226.
• Abdollahi A, Bao R, Hamilton TC (1999). "LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein". Oncogene. 18 (47): 6477–87. doi:10.1038/sj.onc.1203067. PMID 10597250.
• Kamiya M, Judson H, Okazaki Y, Kusakabe M, Muramatsu M, Takada S, Takagi N, Arima T, Wake N, Kamimura K, Satomura K, Hermann R, Bonthron DT, Hayashizaki Y (2000). "The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes". Hum. Mol. Genet. 9 (3): 453–60. doi:10.1093/hmg/9.3.453. PMID 10655556.
• Bilanges B, Varrault A, Mazumdar A, Pantaloni C, Hoffmann A, Bockaert J, Spengler D, Journot L (2001). "Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities". Oncogene. 20 (10): 1246–53. doi:10.1038/sj.onc.1204237. PMID 11313869.
• Huang SM, Schönthal AH, Stallcup MR (2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene. 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197.
• Mackay DJ, Coupe AM, Shield JP, Storr JN, Temple IK, Robinson DO (2002). "Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus". Hum. Genet. 110 (2): 139–44. doi:10.1007/s00439-001-0671-5. PMID 11935319.
• Abdollahi A, Pisarcik D, Roberts D, Weinstein J, Cairns P, Hamilton TC (2003). "LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer". J. Biol. Chem. 278 (8): 6041–9. doi:10.1074/jbc.M210361200. PMID 12473647.
• Hoffmann A, Ciani E, Boeckardt J, Holsboer F, Journot L, Spengler D (2003). "Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding". Mol. Cell. Biol. 23 (3): 988–1003. doi:10.1128/MCB.23.3.988-1003.2003. PMC 140694. PMID 12529403.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Ma D, Shield JP, Dean W, Leclerc I, Knauf C, Burcelin R, Rutter GA, Kelsey G (2004). "Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM". J. Clin. Invest. 114 (3): 339–48. doi:10.1172/JCI19876. PMC 484972. PMID 15286800.
• Cvetkovic D, Pisarcik D, Lee C, Hamilton TC, Abdollahi A (2004). "Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer". Gynecol. Oncol. 95 (3): 449–55. doi:10.1016/j.ygyno.2004.08.051. PMID 15581945.
• Mitchell J, Punthakee Z, Lo B, Bernard C, Chong K, Newman C, Cartier L, Desilets V, Cutz E, Hansen IL, Riley P, Polychronakos C (2004). "Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome". Diabetologia. 47 (12): 2160–7. doi:10.1007/s00125-004-1576-3. PMID 15592663.