PLAC1

Placenta-specific protein 1 is a protein that in humans is encoded by the PLAC1 gene.[5][6]

PLAC1
Identifiers
Aliases	PLAC1, CT92, OOSP2L, placenta specific 1, OOSP2B, placenta enriched 1
External IDs	OMIM: 300296 MGI: 1926287 HomoloGene: 11039 GeneCards: PLAC1
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.3 Start 134,565,838 bp[1] End 134,764,322 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A5|X 29.31 cM Start 53,069,995 bp[2] End 53,240,111 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • molecular function Cellular component • extracellular region • cellular component Biological process • multicellular organism development • placentation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10761	56096
Ensembl	ENSG00000170965	ENSMUSG00000061082
UniProt	Q9HBJ0	Q9JI83
RefSeq (mRNA)	NM_021796 NM_001316887 NM_001316888 NM_001316889	NM_019538 NM_001357802
RefSeq (protein)	NP_001303816 NP_001303817 NP_001303818 NP_068568	NP_062411 NP_001344731
Location (UCSC)	Chr X: 134.57 – 134.76 Mb	Chr X: 53.07 – 53.24 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000170965 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061082 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cocchia M, Huber R, Pantano S, Chen EY, Ma P, Forabosco A, Ko MS, Schlessinger D (Nov 2000). "PLAC1, an Xq26 gene with placenta-specific expression". Genomics. 68 (3): 305–12. doi:10.1006/geno.2000.6302. PMID 10995572.
6. "Entrez Gene: PLAC1 placenta-specific 1".

Further reading

• Fant M, Weisoly DL, Cocchia M, et al. (2003). "PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor". Mol. Reprod. Dev. 63 (4): 430–6. doi:10.1002/mrd.10200. PMID 12412044.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Concu M, Banzola I, Farina A, et al. (2005). "Rapid clearance of mRNA for PLAC1 gene in maternal blood after delivery". Fetal Diagn. Ther. 20 (1): 27–30. doi:10.1159/000081365. PMID 15608456.
• Massabbal E, Parveen S, Weisoly DL, et al. (2005). "PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis". Mol. Reprod. Dev. 71 (3): 299–304. doi:10.1002/mrd.20272. PMID 15803460.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Fujito N, Samura O, Miharu N, et al. (2007). "Increased plasma mRNAs of placenta-specific 1 (PLAC1) and glial cells-missing 1 (GCM1) in mothers with pre-eclampsia". Hiroshima J. Med. Sci. 55 (1): 9–15. PMID 16594548.
• Rizzo N, Banzola I, Concu M, et al. (2007). "PLAC1 mRNA levels in maternal blood at induction of labor correlate negatively with induction-delivery interval". Eur. J. Obstet. Gynecol. Reprod. Biol. 132 (2): 177–81. doi:10.1016/j.ejogrb.2006.05.039. PMID 16860456.
• Fant M, Barerra-Saldana H, Dubinsky W, et al. (2007). "The PLAC1 protein localizes to membranous compartments in the apical region of the syncytiotrophoblast". Mol. Reprod. Dev. 74 (7): 922–9. doi:10.1002/mrd.20673. PMID 17186554.
• Purwosunu Y, Sekizawa A, Farina A, et al. (2007). "Cell-free mRNA concentrations of CRH, PLAC1, and selectin-P are increased in the plasma of pregnant women with preeclampsia". Prenat. Diagn. 27 (8): 772–7. doi:10.1002/pd.1780. PMID 17554801.
• Koslowski M, Sahin U, Mitnacht-Kraus R, et al. (2007). "A placenta-specific gene ectopically activated in many human cancers is essentially involved in malignant cell processes". Cancer Res. 67 (19): 9528–34. doi:10.1158/0008-5472.CAN-07-1350. PMID 17909063.