PLA2G4C

Cytosolic phospholipase A2 gamma is an enzyme that in humans is encoded by the PLA2G4C gene.[5][6]

PLA2G4C
Identifiers
Aliases	PLA2G4C, CPLA2-gamma, phospholipase A2 group IVC
External IDs	OMIM: 603602 MGI: 1196403 HomoloGene: 115256 GeneCards: PLA2G4C
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 48,047,843 bp[1] End 48,110,817 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A1|7 7.84 cM Start 13,324,655 bp[2] End 13,360,672 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • phospholipase activity • calcium-independent phospholipase A2 activity • phospholipid binding • hydrolase activity • phospholipase A2 activity • phospholipase A1 activity • lysophospholipase activity • phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) • phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) • calcium ion binding • calcium-dependent phospholipid binding • calcium-dependent phospholipase A2 activity Cellular component • cytosol • endoplasmic reticulum membrane • membrane • nuclear envelope • nucleoplasm • cell cortex • cytoplasm Biological process • GO:0007243 intracellular signal transduction • phosphatidylethanolamine acyl-chain remodeling • glycerophospholipid catabolic process • lipid metabolism • phosphatidylinositol acyl-chain remodeling • lipid catabolic process • birth • phospholipid catabolic process • phospholipid metabolic process • metabolism • inflammatory response • arachidonic acid metabolic process • phosphatidylcholine acyl-chain remodeling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8605	232889
Ensembl	ENSG00000105499	ENSMUSG00000033847
UniProt	Q9UP65	Q64GA5
RefSeq (mRNA)	NM_001159322 NM_001159323 NM_003706	NM_001004762 NM_001168504
RefSeq (protein)	NP_001152794 NP_001152795 NP_003697 NP_003697.2	NP_001004762 NP_001161976
Location (UCSC)	Chr 19: 48.05 – 48.11 Mb	Chr 7: 13.32 – 13.36 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000105499 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033847 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Underwood KW, Song C, Kriz RW, Chang XJ, Knopf JL, Lin LL (Sep 1998). "A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2". J Biol Chem. 273 (34): 21926–32. doi:10.1074/jbc.273.34.21926. PMID 9705332.
6. "Entrez Gene: PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)".

Further reading

• Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
• Wu T, Angus CW, Yao XL, et al. (1997). "P11, a unique member of the S100 family of calcium-binding proteins, interacts with and inhibits the activity of the 85-kDa cytosolic phospholipase A2". J. Biol. Chem. 272 (27): 17145–53. doi:10.1074/jbc.272.27.17145. PMID 9202034.
• Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi:10.1097/00042560-199709010-00001. PMID 9377118.
• Pickard RT, Strifler BA, Kramer RM, Sharp JD (1999). "Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2". J. Biol. Chem. 274 (13): 8823–31. doi:10.1074/jbc.274.13.8823. PMID 10085124.
• Smith JS, Tachibana I, Pohl U, et al. (2000). "A transcript map of the chromosome 19q-arm glioma tumor suppressor region". Genomics. 64 (1): 44–50. doi:10.1006/geno.1999.6101. PMID 10708517.
• Hartmann C, Johnk L, Sasaki H, et al. (2002). "Novel PLA2G4C polymorphism as a molecular diagnostic assay for 19q loss in human gliomas". Brain Pathol. 12 (2): 178–82. doi:10.1111/j.1750-3639.2002.tb00432.x. PMID 11958371.
• Stewart A, Ghosh M, Spencer DM, Leslie CC (2002). "Enzymatic properties of human cytosolic phospholipase A(2)gamma". J. Biol. Chem. 277 (33): 29526–36. doi:10.1074/jbc.M204856200. PMID 12039969.
• Lindbom J, Ljungman AG, Lindahl M, Tagesson C (2003). "Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma". J. Interferon Cytokine Res. 22 (9): 947–55. doi:10.1089/10799900260286650. PMID 12396716.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Asai K, Hirabayashi T, Houjou T, et al. (2003). "Human group IVC phospholipase A2 (cPLA2gamma). Roles in the membrane remodeling and activation induced by oxidative stress". J. Biol. Chem. 278 (10): 8809–14. doi:10.1074/jbc.M212117200. PMID 12502717.
• Jenkins CM, Han X, Yang J, et al. (2004). "Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis". Biochemistry. 42 (40): 11798–807. doi:10.1021/bi034611q. PMID 14529291.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dong M, Johnson M, Rezaie A, et al. (2005). "Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis". Clin. Cancer Res. 11 (6): 2265–71. doi:10.1158/1078-0432.CCR-04-1079. PMID 15788676.
• Yan W, Jenkins CM, Han X, et al. (2005). "The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling". J. Biol. Chem. 280 (29): 26669–79. doi:10.1074/jbc.M502358200. PMID 15908428.
• Yamashita A, Kamata R, Kawagishi N, et al. (2005). "Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)". J. Biochem. 137 (5): 557–67. doi:10.1093/jb/mvi067. PMID 15944408.
• Zhao X, Wang D, Zhao Z, et al. (2006). "Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells". J. Biol. Chem. 281 (39): 29357–68. doi:10.1074/jbc.M513105200. PMID 16882668.