PKIA

cAMP-dependent protein kinase inhibitor alpha is a protein that in humans is encoded by the PKIA gene.[5][6]

This article is about the protein encoded by the PKIA gene in humans. For the military casualty classification, see Killed in action.

PKIA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CMK, 1JLU, 1Q8T, 1XH4, 1XH5, 1XH6, 1XH7, 1XH8, 1XH9, 1XHA, 1YDR, 2C1A, 2C1B, 2F7E, 2GNI, 2JDS, 2JDT, 2JDV, 2L1L, 2UVY, 2UVZ, 2UW0, 2UW3, 2UW4, 2UW5, 2UW6, 2UW7, 2UW8, 2VNW, 2VNY, 2VO0, 2VO3, 2VO6, 2VO7, 3AMA, 3AMB, 3L9L, 3L9M, 3L9N, 3MVJ, 3NX8, 3OOG, 3OVV, 3OWP, 3OXT, 3P0M, 3POO, 3VQH, 3WYG, 4AXA, 4IAC, 4IAD, 4IAF, 4IAI, 4IAK, 4IAY, 4IAZ, 4IB0, 4IB1, 4IB3, 4IE9, 4IJ9, 4O21, 4O22, 4WB5, 4WB6, 4WB7, 4WB8, 4Z83, 4Z84, 5DH9, 1Q61, 3X2U, 3X2W, 1Q62, 3X2V, 4UJA, 4UJ9, 4UJB, 4UJ2, 4UJ1
Identifiers
Aliases	PKIA, PRKACN1, protein kinase (cAMP-dependent, catalytic) inhibitor alpha, cAMP-dependent protein kinase inhibitor alpha
External IDs	OMIM: 606059 MGI: 104747 HomoloGene: 7473 GeneCards: PKIA
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.13 Start 78,516,340 bp[1] End 78,605,267 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A1 Start 7,366,669 bp[2] End 7,445,366 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein kinase inhibitor activity • GO:0001948 protein binding • cAMP-dependent protein kinase inhibitor activity • protein kinase A catalytic subunit binding • kinase activity Cellular component • cytoplasm • cell nucleus Biological process • regulation of G2/M transition of mitotic cell cycle • GO:0048553 negative regulation of catalytic activity • negative regulation of transcription from RNA polymerase II promoter • negative regulation of cAMP-dependent protein kinase activity • negative regulation of protein kinase activity • negative regulation of protein import into nucleus • negative regulation of protein serine/threonine kinase activity • phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5569	18767
Ensembl	ENSG00000171033	ENSMUSG00000027499
UniProt	P61925	P63248
RefSeq (mRNA)	NM_181839 NM_006823	NM_008862
RefSeq (protein)	NP_006814 NP_862822 NP_006814.1 NP_862822.1	NP_032888
Location (UCSC)	Chr 8: 78.52 – 78.61 Mb	Chr 3: 7.37 – 7.45 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000171033 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027499 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Olsen SR, Uhler MD (Feb 1992). "Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor". Mol Endocrinol. 5 (9): 1246–1256. doi:10.1210/mend-5-9-1246. PMID 1770951.
6. "Entrez Gene: PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha".

Further reading

• Olsen SR, Uhler MD (1991). "Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase". J. Biol. Chem. 266 (17): 11158–11162. PMID 1710219.
• Knighton DR, Zheng JH, Ten Eyck LF, et al. (1991). "Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase". Science. 253 (5018): 414–420. doi:10.1126/science.1862343. PMID 1862343.
• Van Patten SM, Heisermann GJ, Cheng HC, Walsh DA (1987). "Tyrosine kinase catalyzed phosphorylation and inactivation of the inhibitor protein of the cAMP-dependent protein kinase". J. Biol. Chem. 262 (7): 3398–3403. PMID 2434500.
• Scott JD, Fischer EH, Demaille JG, Krebs EG (1985). "Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase". Proc. Natl. Acad. Sci. U.S.A. 82 (13): 4379–4383. doi:10.1073/pnas.82.13.4379. PMC 390417. PMID 2989819.
• Scott JD, Glaccum MB, Fischer EH, Krebs EG (1986). "Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase". Proc. Natl. Acad. Sci. U.S.A. 83 (6): 1613–1616. doi:10.1073/pnas.83.6.1613. PMC 323133. PMID 3456605.
• Wen W, Taylor SS, Meinkoth JL (1995). "The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated". J. Biol. Chem. 270 (5): 2041–2046. doi:10.1074/jbc.270.5.2041. PMID 7836431.
• Baude EJ, Dignam SS, Olsen SR, et al. (1994). "Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor". J. Biol. Chem. 269 (3): 2316–2323. PMID 7905001.
• Baude EJ, Dignam SS, Reimann EM, Uhler MD (1994). "Evidence for the importance of hydrophobic residues in the interactions between the cAMP-dependent protein kinase catalytic subunit and the protein kinase inhibitors". J. Biol. Chem. 269 (27): 18128–18133. PMID 8027074.
• Fritz CC, Green MR (1997). "HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs". Curr. Biol. 6 (7): 848–854. doi:10.1016/S0960-9822(02)00608-5. PMID 8805303.
• Zimmermann B, Chiorini JA, Ma Y, et al. (1999). "PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I". J. Biol. Chem. 274 (9): 5370–5378. doi:10.1074/jbc.274.9.5370. PMID 10026146.
• Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res. 99 (2): 145–149. doi:10.1016/S0169-328X(02)00104-3. PMID 11978406.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gassel M, Breitenlechner CB, Rüger P, et al. (2003). "Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT)". J. Mol. Biol. 329 (5): 1021–1034. doi:10.1016/S0022-2836(03)00518-7. PMID 12798691.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.