PKD2L1

Polycystic kidney disease 2-like 1 protein also known as transient receptor potential polycystic 2 (TRPP2; formerly TRPP3) is a protein that in humans is encoded by the PKD2L1 gene.[5]

PKD2L1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPKD2L1, PCL, PKD2L, PKDL, TRPP3, polycystin 2 like 1, transient receptor potential cation channel
External IDsOMIM: 604532 MGI: 1352448 HomoloGene: 22946 GeneCards: PKD2L1
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q24.31Start100,288,149 bp[1]
End100,330,264 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9033

329064

Ensembl

ENSG00000107593

ENSMUSG00000037578

UniProt

Q9P0L9

A2A259

RefSeq (mRNA)

NM_001253837
NM_016112

NM_181422

RefSeq (protein)

NP_001240766
NP_057196

NP_852087

Location (UCSC)Chr 10: 100.29 – 100.33 MbChr 19: 44.15 – 44.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

TRPP2 is a member of the polycystin protein family. TRPP2 contains multiple transmembrane domains, and cytoplasmic N- and C-termini. TRPP2 may be an integral membrane protein involved in cell-cell/matrix interactions. TRPP2 functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.[5]

Interactions

PKD2L1 has been shown to interact with TNNI3.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000107593 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037578 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: PKD2L1 polycystic kidney disease 2-like 1".
  6. Li Q, Liu Y, Shen PY, Dai XQ, Wang S, Smillie LB, Sandford R, Chen XZ (June 2003). "Troponin I binds polycystin-L and inhibits its calcium-induced channel activation". Biochemistry. 42 (24): 7618–25. doi:10.1021/bi034210a. PMID 12809519.

Further reading


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