PIN4

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 is an enzyme that in humans is encoded by the PIN4 gene.[5][6][7]

PIN4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EQ3, 1FJD, 3UI4, 3UI5, 3UI6
Identifiers
Aliases	PIN4, EPVH, PAR14, PAR17, peptidylprolyl cis/trans isomerase, NIMA-interacting 4
External IDs	OMIM: 300252 MGI: 1916963 HomoloGene: 121907 GeneCards: PIN4
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 72,181,353 bp[1] End 72,302,926 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X D Start 102,119,447 bp[2] End 102,127,669 bp[2]
Gene ontology Molecular function • DNA binding • double-stranded DNA binding • GO:0001948 protein binding • bent DNA binding • isomerase activity • peptidyl-prolyl cis-trans isomerase activity • RNA binding Cellular component • cytoplasm • mitochondrial matrix • spindle • preribosome • nucleolus • extracellular exosome • cytoskeleton • mitochondrion • cell nucleus Biological process • rRNA processing • protein peptidyl-prolyl isomerization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5303	69713
Ensembl	ENSG00000102309	ENSMUSG00000079480
UniProt	Q9Y237	Q9CWW6
RefSeq (mRNA)	NM_001170747 NM_006223	NM_027181
RefSeq (protein)	NP_001164218 NP_006214	NP_081457 NP_001352019
Location (UCSC)	Chr X: 72.18 – 72.3 Mb	Chr X: 102.12 – 102.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000102309 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000079480 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mueller JW, Kessler D, Neumann D, Stratmann T, Papatheodorou P, Hartmann-Fatu C, Bayer P (Mar 2006). "Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation". BMC Mol Biol. 7: 9. doi:10.1186/1471-2199-7-9. PMC 1420321. PMID 16522211.
6. Kessler D, Papatheodorou P, Stratmann T, Dian EA, Hartmann-Fatu C, Rassow J, Bayer P, Mueller JW (Oct 2007). "The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae". BMC Biol. 5: 37. doi:10.1186/1741-7007-5-37. PMC 2031878. PMID 17875217.
7. "Entrez Gene: PIN4 protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)".

Further reading

• Uchida T, Fujimori F, Tradler T, et al. (1999). "Identification and characterization of a 14 kDa human protein as a novel parvulin-like peptidyl prolyl cis/trans isomerase". FEBS Lett. 446 (2–3): 278–82. doi:10.1016/S0014-5793(99)00239-2. PMID 10100858.
• Rulten S, Thorpe J, Kay J (1999). "Identification of eukaryotic parvulin homologues: a new subfamily of peptidylprolyl cis-trans isomerases". Biochem. Biophys. Res. Commun. 259 (3): 557–62. doi:10.1006/bbrc.1999.0828. PMID 10364457.
• Sekerina E, Rahfeld JU, Müller J, et al. (2000). "NMR solution structure of hPar14 reveals similarity to the peptidyl prolyl cis/trans isomerase domain of the mitotic regulator hPin1 but indicates a different functionality of the protein". J. Mol. Biol. 301 (4): 1003–17. doi:10.1006/jmbi.2000.4013. PMID 10966801.
• Terada T, Shirouzu M, Fukumori Y, et al. (2001). "Solution structure of the human parvulin-like peptidyl prolyl cis/trans isomerase, hPar14". J. Mol. Biol. 305 (4): 917–26. doi:10.1006/jmbi.2000.4293. PMID 11162102.
• Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
• Fujiyama S, Yanagida M, Hayano T, et al. (2002). "Isolation and proteomic characterization of human Parvulin-associating preribosomal ribonucleoprotein complexes". J. Biol. Chem. 277 (26): 23773–80. doi:10.1074/jbc.M201181200. PMID 11960984.
• Surmacz TA, Bayer E, Rahfeld JU, et al. (2002). "The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding". J. Mol. Biol. 321 (2): 235–47. doi:10.1016/S0022-2836(02)00615-0. PMID 12144781.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Reimer T, Weiwad M, Schierhorn A, et al. (2003). "Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14". J. Mol. Biol. 330 (5): 955–66. doi:10.1016/S0022-2836(03)00713-7. PMID 12860119.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.