PIK3R5

Phosphoinositide 3-kinase regulatory subunit 5 is an enzyme that in humans is encoded by the PIK3R5 gene.[5][6]

PIK3R5
Identifiers
Aliases	PIK3R5, F730038I15Rik, FOAP-2, P101-PI3K, p101, phosphoinositide-3-kinase regulatory subunit 5
External IDs	OMIM: 611317 MGI: 2443588 HomoloGene: 8627 GeneCards: PIK3R5
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 8,878,911 bp[1] End 8,965,712 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 68,432,121 bp[2] End 68,497,849 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein beta/gamma-subunit complex binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase regulator activity Cellular component • cytoplasm • cell membrane • phosphatidylinositol 3-kinase complex, class IB • membrane • cell nucleus • phosphatidylinositol 3-kinase complex • microtubule organizing center • cytosol Biological process • platelet activation • positive regulation of protein kinase B signaling • regulation of phosphatidylinositol 3-kinase activity • positive regulation of MAP kinase activity • phosphatidylinositol 3-kinase signaling • phosphatidylinositol phosphorylation • G-protein coupled receptor signaling pathway • positive regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23533	320207
Ensembl	ENSG00000141506	ENSMUSG00000020901
UniProt	Q8WYR1	Q5SW28
RefSeq (mRNA)	NM_001142633 NM_001251851 NM_001251852 NM_001251853 NM_001251855 NM_014308	NM_177320
RefSeq (protein)	NP_001136105 NP_001238780 NP_001238781 NP_001238782 NP_001238784 NP_055123	NP_796294.2 NP_796294
Location (UCSC)	Chr 17: 8.88 – 8.97 Mb	Chr 11: 68.43 – 68.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PIK3R5 has been shown to interact with PIK3CG.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000141506 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020901 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brock C, Schaefer M, Reusch HP, Czupalla C, Michalke M, Spicher K, Schultz G, Nurnberg B (Jan 2003). "Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma". J Cell Biol. 160 (1): 89–99. doi:10.1083/jcb.200210115. PMC 2172741. PMID 12507995.
6. "Entrez Gene: PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5, p101".

Further reading

• Johnson C, Marriott SJ, Levy LS (2007). "Overexpression of p101 activates PI3Kgamma signaling in T cells and contributes to cell survival". Oncogene. 26 (49): 7049–57. doi:10.1038/sj.onc.1210504. PMID 17486067.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Suire S, Coadwell J, Ferguson GJ, et al. (2005). "p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma". Curr. Biol. 15 (6): 566–70. doi:10.1016/j.cub.2005.02.020. PMID 15797027.
• Voigt P, Brock C, Nürnberg B, Schaefer M (2005). "Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma". J. Biol. Chem. 280 (6): 5121–7. doi:10.1074/jbc.M413104200. PMID 15611065.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Metjian A, Roll RL, Ma AD, Abrams CS (1999). "Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus". J. Biol. Chem. 274 (39): 27943–7. doi:10.1074/jbc.274.39.27943. PMID 10488142.
• Krugmann S, Hawkins PT, Pryer N, Braselmann S (1999). "Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits". J. Biol. Chem. 274 (24): 17152–8. doi:10.1074/jbc.274.24.17152. PMID 10358071.