PIK3IP1

Phosphoinositide-3-kinase-interacting protein 1 is an enzyme that in humans is encoded by the PIK3IP1 gene.[5][6]

PIK3IP1
Identifiers
Aliases	PIK3IP1, HGFL, hHGFL(S), phosphoinositide-3-kinase interacting protein 1, TrIP
External IDs	MGI: 1917016 HomoloGene: 14166 GeneCards: PIK3IP1
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 31,281,594 bp[1] End 31,292,534 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 3,330,401 bp[2] End 3,342,971 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • phosphatidylinositol 3-kinase catalytic subunit binding • GO:0001948 protein binding Cellular component • integral component of membrane • cell membrane • membrane Biological process • negative regulation of phosphatidylinositol 3-kinase signaling • negative regulation of phosphatidylinositol 3-kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	113791	216505
Ensembl	ENSG00000100100	ENSMUSG00000034614
UniProt	Q96FE7	Q7TMJ8
RefSeq (mRNA)	NM_052880 NM_001135911	NM_178149
RefSeq (protein)	NP_001129383 NP_443112	NP_835362
Location (UCSC)	Chr 22: 31.28 – 31.29 Mb	Chr 11: 3.33 – 3.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000100100 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034614 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
6. "Entrez Gene: MGC17330 HGFL gene".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Zhu Z, He X, Johnson C, et al. (2007). "PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein". Biochem. Biophys. Res. Commun. 358 (1): 66–72. doi:10.1016/j.bbrc.2007.04.096. PMC 1978172. PMID 17475214.