PIB5PA

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A is an enzyme that in humans is encoded by the INPP5J gene.[5][6]

INPP5J
Identifiers
Aliases	INPP5J, INPP5, PIB5PA, PIPP, inositol polyphosphate-5-phosphatase J
External IDs	OMIM: 606481 MGI: 2158663 HomoloGene: 8682 GeneCards: INPP5J
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 31,122,731 bp[1] End 31,134,697 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 3,494,375 bp[2] End 3,504,821 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • SH3 domain binding • inositol-polyphosphate 5-phosphatase activity • GO:0001948 protein binding • hydrolase activity • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity • inositol-1,4,5-trisphosphate 5-phosphatase activity • inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Cellular component • cytoplasm • ruffle • growth cone • dendritic shaft • cytosol • cell membrane Biological process • phosphatidylinositol biosynthetic process • negative regulation of neuron projection development • inositol phosphate metabolic process • negative regulation of microtubule polymerization • phosphatidylinositol dephosphorylation • negative regulation of peptidyl-serine phosphorylation • inositol phosphate dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27124	170835
Ensembl	ENSG00000185133	ENSMUSG00000034570
UniProt	Q15735	P59644
RefSeq (mRNA)	NM_001002837 NM_001284285 NM_001284286 NM_001284287 NM_001284288 NM_001284289 NM_014422	NM_172439
RefSeq (protein)	NP_001002837 NP_001271214 NP_001271215 NP_001271216 NP_001271217 NP_001271218	NP_766027
Location (UCSC)	Chr 22: 31.12 – 31.13 Mb	Chr 11: 3.49 – 3.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000185133 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034570 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
6. "Entrez Gene: PIB5PA phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gurung R, Tan A, Ooms LM, et al. (2003). "Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation". J. Biol. Chem. 278 (13): 11376–85. doi:10.1074/jbc.M209991200. PMID 12536145.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mochizuki Y, Takenawa T (2000). "Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles". J. Biol. Chem. 274 (51): 36790–5. doi:10.1074/jbc.274.51.36790. PMID 10593988.
• Krämer J, Aguirre-Arteta AM, Thiel C, et al. (1999). "A novel isoform of the smooth muscle cell differentiation marker smoothelin". J. Mol. Med. 77 (2): 294–8. doi:10.1007/s001090050352. PMID 10023782.
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.