PGPEP1

The PGPEP1 gene in humans encodes the enzyme Pyroglutamyl-peptidase I.[5]

PGPEP1
Identifiers
Aliases	PGPEP1, PAP-I, PGP, PGP-I, PGPI, Pcp, pyroglutamyl-peptidase I, PGI
External IDs	OMIM: 610694 MGI: 1913772 HomoloGene: 9793 GeneCards: PGPEP1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 18,340,598 bp[1] End 18,369,950 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 70,646,435 bp[2] End 70,660,388 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase activity • cysteine-type peptidase activity • hydrolase activity • pyroglutamyl-peptidase activity Cellular component • cytoplasm • cytosol Biological process • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54858	66522
Ensembl	ENSG00000130517	ENSMUSG00000056204
UniProt	Q9NXJ5	Q9ESW8
RefSeq (mRNA)	NM_001300927 NM_001308366 NM_017712 NM_001329471 NM_001329476 NM_001329477 NM_001329478	NM_023217
RefSeq (protein)	NP_001287856 NP_001295295 NP_001316400 NP_001316405 NP_001316406 NP_001316407 NP_060182	NP_075706
Location (UCSC)	Chr 19: 18.34 – 18.37 Mb	Chr 8: 70.65 – 70.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000130517 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056204 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PGPEP1 pyroglutamyl-peptidase I".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Valdivia A, Irazusta J, Fernández D, et al. (2005). "Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia". Regul. Pept. 122 (2): 79–84. doi:10.1016/j.regpep.2004.05.005. PMID 15380924.
• Minderman H, O'Loughlin KL, Pendyala L, Baer MR (2004). "VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein". Clin. Cancer Res. 10 (5): 1826–34. doi:10.1158/1078-0432.CCR-0914-3. PMID 15014037.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dando PM, Fortunato M, Strand GB, et al. (2003). "Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme". Protein Expr. Purif. 28 (1): 111–9. doi:10.1016/S1046-5928(02)00632-0. PMID 12651114.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gil J, Larrinaga G, Meana JJ, et al. (2002). "Regional and subcellular distribution of soluble aminopeptidase in the human and the rat brain: a comparative study". Neuropeptides. 35 (5–6): 276–84. doi:10.1054/npep.2001.0870. PMID 12030812.
• Charli JL, Mendez M, Vargas MA, et al. (1990). "Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices". Neuropeptides. 14 (3): 191–6. doi:10.1016/0143-4179(89)90044-9. PMID 2575716.