Peptidoglycan recognition protein 2

PGLYRP2 is a gene encoding a protein with N-acetylmuramoyl-L-alanine amidase activity.[5][6][7]

PGLYRP2
Identifiers
Aliases	PGLYRP2, HMFT0141, PGLYRPL, PGRP-L, PGRPL, TAGL-like, tagL, tagL-alpha, tagl-beta, peptidoglycan recognition protein 2
External IDs	OMIM: 608199 MGI: 1928099 HomoloGene: 49671 GeneCards: PGLYRP2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 15,468,645 bp[1] End 15,498,956 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 32,412,459 bp[2] End 32,424,167 bp[2]
Gene ontology Molecular function • metal ion binding • zinc ion binding • hydrolase activity • peptidoglycan receptor activity • peptidoglycan binding • N-acetylmuramoyl-L-alanine amidase activity Cellular component • intracellular • membrane • extracellular exosome • extracellular region • extracellular Biological process • immune system process • peptide amidation • negative regulation of natural killer cell differentiation involved in immune response • negative regulation of interferon-gamma production • growth of symbiont in host • innate immune system • detection of bacterium • regulation of inflammatory response • defense response to Gram-positive bacterium • peptidoglycan catabolic process • pattern recognition receptor signaling pathway • antimicrobial humoral response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114770	57757
Ensembl	ENSG00000161031	ENSMUSG00000079563
UniProt	Q96PD5	Q8VCS0
RefSeq (mRNA)	NM_052890 NM_001363546	NM_001271476 NM_001271477 NM_001271478 NM_001271479 NM_021319
RefSeq (protein)	NP_443122 NP_001350475	NP_001258405 NP_001258406 NP_001258407 NP_001258408 NP_067294
Location (UCSC)	Chr 19: 15.47 – 15.5 Mb	Chr 17: 32.41 – 32.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Peptidoglycan recognition proteins, such as PGRPL, are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls.[supplied by OMIM][7]

See also

• Peptidoglycan
• Innate immune system
• Bacterial cell walls

References

1. GRCh38: Ensembl release 89: ENSG00000161031 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000079563 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Liu C, Xu Z, Gupta D, Dziarski R (Sep 2001). "Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules". J Biol Chem. 276 (37): 34686–94. doi:10.1074/jbc.M105566200. PMID 11461926.
6. Kibardin AV, Mirkina II, Zakeeva IR, Baranova EV, Georgiev GP, Kiselev SL (Apr 2003). "[Expression analysis of proteins encoded by genes of the tag7/tagL (PGRP-S,L) family in human peripheral blood cells]". Genetika. 39 (2): 244–9. PMID 12669421.
7. "Entrez Gene: PGLYRP2 peptidoglycan recognition protein 2".

Further reading

• De Pauw P, Neyt C, Vanderwinkel E, et al. (1995). "Characterization of human serum N-acetylmuramyl-L-alanine amidase purified by affinity chromatography". Protein Expr. Purif. 6 (3): 371–8. doi:10.1006/prep.1995.1049. PMID 7663175.
• Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184.
• Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
• Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Wang ZM, Li X, Cocklin RR, et al. (2004). "Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase". J. Biol. Chem. 278 (49): 49044–52. doi:10.1074/jbc.M307758200. PMID 14506276.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID 15221005.
• Xu M, Wang Z, Locksley RM (2004). "Innate immune responses in peptidoglycan recognition protein L-deficient mice". Mol. Cell. Biol. 24 (18): 7949–57. doi:10.1128/MCB.24.18.7949-7957.2004. PMC 515053. PMID 15340057.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Zhang Y, van der Fits L, Voerman JS, et al. (2005). "Identification of serum N-acetylmuramoyl-l-alanine amidase as liver peptidoglycan recognition protein 2". Biochim. Biophys. Acta. 1752 (1): 34–46. doi:10.1016/j.bbapap.2005.07.001. PMID 16054449.
• Wang H, Gupta D, Li X, Dziarski R (2005). "Peptidoglycan recognition protein 2 (N-acetylmuramoyl-L-Ala amidase) is induced in keratinocytes by bacteria through the p38 kinase pathway". Infect. Immun. 73 (11): 7216–25. doi:10.1128/IAI.73.11.7216-7225.2005. PMC 1273900. PMID 16239516.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Li X, Wang S, Wang H, Gupta D (2006). "Differential expression of peptidoglycan recognition protein 2 in the skin and liver requires different transcription factors". J. Biol. Chem. 281 (30): 20738–48. doi:10.1074/jbc.M601017200. PMID 16714290.