PGK1
Phosphoglycerate kinase 1 is an enzyme that in humans is encoded by the PGK1 gene.[5][6][7]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
Glycolysis and Gluconeogenesis edit
- The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".
gollark: If the probability of false positives is low relative to the number of possible keys, it's probably fine™.
gollark: I don't think you can *in general*, but you'll probably know in some cases what the content might be. Lots of network protocols and such include checksums and headers and defined formats, which can be validated, and English text could be detected.
gollark: But having access to several orders of magnitude of computing power than exists on Earth, and quantum computers (which can break the hard problems involved in all widely used asymmetric stuff) would.
gollark: Like how in theory on arbitrarily big numbers the fastest way to do multiplication is with some insane thing involving lots of Fourier transforms, but on averagely sized numbers it isn't very helpful.
gollark: It's entirely possible that the P = NP thing could be entirely irrelevant to breaking encryption, actually, as it might not provide a faster/more computationally efficient algorithm for key sizes which are in use.
References
- GRCh38: Ensembl release 89: ENSG00000102144 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000062070 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Michelson AM, Markham AF, Orkin SH (May 1983). "Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase". Proc Natl Acad Sci U S A. 80 (2): 472–6. doi:10.1073/pnas.80.2.472. PMC 393400. PMID 6188151.
- Singer-Sam J, Keith DH, Tani K, Simmer RL, Shively L, Lindsay S, Yoshida A, Riggs AD (May 1985). "Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase]". Gene. 32 (3): 409–17. doi:10.1016/0378-1119(84)90016-7. PMID 6099325.
- "Entrez Gene: PGK1 phosphoglycerate kinase 1".
Further reading
- Vishwanatha JK, Jindal HK, Davis RG (1992). "The role of primer recognition proteins in DNA replication: association with nuclear matrix in HeLa cells". J. Cell Sci. 101. ( Pt 1): 25–34. PMID 1533225.
- Fujii H, Kanno H, Hirono A, et al. (1992). "A single amino acid substitution (157 Gly----Val) in a phosphoglycerate kinase variant (PGK Shizuoka) associated with chronic hemolysis and myoglobinuria". Blood. 79 (6): 1582–5. PMID 1547346.
- Maeda M, Bawle EV, Kulkarni R, et al. (1992). "Molecular abnormalities of a phosphoglycerate kinase variant generated by spontaneous mutation". Blood. 79 (10): 2759–62. PMID 1586722.
- Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
- Kumble KD, Vishwanatha JK (1992). "Immunoelectron microscopic analysis of the intracellular distribution of primer recognition proteins, annexin 2 and phosphoglycerate kinase, in normal and transformed cells". J. Cell Sci. 99. ( Pt 4): 751–8. PMID 1837552.
- Maeda M, Yoshida A (1991). "Molecular defect of a phosphoglycerate kinase variant (PGK-Matsue) associated with hemolytic anemia: Leu----Pro substitution caused by T/A----C/G transition in exon 3". Blood. 77 (6): 1348–52. PMID 2001457.
- Jindal HK, Vishwanatha JK (1990). "Functional identity of a primer recognition protein as phosphoglycerate kinase". J. Biol. Chem. 265 (12): 6540–3. PMID 2324090.
- Johnson P, Friedmann T (1990). "Limited bidirectional activity of two housekeeping gene promoters: human HPRT and PGK". Gene. 88 (2): 207–13. doi:10.1016/0378-1119(90)90033-N. PMID 2347494.
- Pfeifer GP, Steigerwald SD, Mueller PR, et al. (1989). "Genomic sequencing and methylation analysis by ligation mediated PCR". Science. 246 (4931): 810–3. doi:10.1126/science.2814502. PMID 2814502.
- Michelson AM, Blake CC, Evans ST, Orkin SH (1985). "Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain". Proc. Natl. Acad. Sci. U.S.A. 82 (20): 6965–9. doi:10.1073/pnas.82.20.6965. PMC 391290. PMID 2995995.
- McCarrey JR, Thomas K (1987). "Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene". Nature. 326 (6112): 501–5. doi:10.1038/326501a0. PMID 3453121.
- Fujii H, Yoshida A (1981). "Molecular abnormality of phosphoglycerate kinase-Uppsala associated with chronic nonspherocytic hemolytic anemia". Proc. Natl. Acad. Sci. U.S.A. 77 (9): 5461–5. doi:10.1073/pnas.77.9.5461. PMC 350080. PMID 6933565.
- Fujii H, Chen SH, Akatsuka J, et al. (1981). "Use of cultured lymphoblastoid cells for the study of abnormal enzymes: molecular abnormality of a phosphoglycerate kinase variant associated with hemolytic anemia". Proc. Natl. Acad. Sci. U.S.A. 78 (4): 2587–90. doi:10.1073/pnas.78.4.2587. PMC 319394. PMID 6941312.
- Huang IY, Welch CD, Yoshida A (1980). "Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence". J. Biol. Chem. 255 (13): 6412–20. PMID 7391027.
- Fujii H, Krietsch WK, Yoshida A (1980). "A single amino acid substitution (Asp leads to Asn) in a phosphoglycerate kinase variant (PGK München) associated with enzyme deficiency". J. Biol. Chem. 255 (13): 6421–3. PMID 7391028.
- Huang IY, Fujii H, Yoshida A (1981). "Structure and function of normal and variant human phosphoglycerate kinase". Hemoglobin. 4 (5–6): 601–9. doi:10.3109/03630268008997730. PMID 7440217.
- Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
- Hershkovitz M, Riggs AD (1995). "Metaphase chromosome analysis by ligation-mediated PCR: heritable chromatin structure and a comparison of active and inactive X chromosomes". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2379–83. doi:10.1073/pnas.92.6.2379. PMC 42487. PMID 7892275.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Phosphoglycerate kinase 1
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