PGAP1

Post-GPI attachment to proteins 1 is a protein that in humans is encoded by the PGAP1 gene.[5]

PGAP1
Identifiers
Aliases	PGAP1, Bst1, ISPD3024, MRT42, SPG67, post-GPI attachment to proteins 1, post-GPI attachment to proteins inositol deacylase 1
External IDs	OMIM: 611655 MGI: 2443342 HomoloGene: 41605 GeneCards: PGAP1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.1 Start 196,833,004 bp[1] End 196,927,796 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C1.1-C1.2 Start 54,472,994 bp[2] End 54,557,684 bp[2]
Gene ontology Molecular function • nuclease activity • phosphoric ester hydrolase activity • hydrolase activity • hydrolase activity, acting on ester bonds • phosphatidylinositol deacylase activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum Biological process • embryonic pattern specification • nucleic acid phosphodiester bond hydrolysis • head development • attachment of GPI anchor to protein • sensory perception of sound • forebrain regionalization • protein transport • GPI anchor biosynthetic process • myo-inositol transport • anterior/posterior axis specification • GPI anchor metabolic process • ER to Golgi vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80055	241062
Ensembl	ENSG00000197121	ENSMUSG00000073678
UniProt	Q75T13	Q3UUQ7
RefSeq (mRNA)	NM_024989 NM_001321099 NM_001321100	NM_001163314 NM_175508
RefSeq (protein)	NP_001308028 NP_001308029 NP_079265	NP_001156786
Location (UCSC)	Chr 2: 196.83 – 196.93 Mb	Chr 1: 54.47 – 54.56 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene functions early in the glycosylphosphatidylinositol (GPI) biosynthetic pathway, catalyzing the inositol deacylation of GPI. The encoded protein is required for the production of GPI that can attach to proteins, and this may be an important factor in the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi. Defects in this gene are a cause of mental retardation, autosomal recessive 42.

References

1. GRCh38: Ensembl release 89: ENSG00000197121 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073678 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Post-GPI attachment to proteins 1". Retrieved 2016-04-04.

Further reading

• Tanaka S, Maeda Y, Tashima Y, Kinoshita T (2004). "Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p". J. Biol. Chem. 279 (14): 14256–63. doi:10.1074/jbc.M313755200. PMID 14734546.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.