PGAM5

PGAM family member 5 (PGAM5), also known as mitochondrial Serine/threonine-protein phosphatase PGAM5 is related to phosphoglycerate mutase family. It, in humans, is encoded by the PGAM5 gene on chromosome 12.[5][6]

PGAM5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MXO, 3O0T
Identifiers
Aliases	PGAM5, BXLBV68, PGAM family member 5, mitochondrial serine/threonine protein phosphatase
External IDs	OMIM: 614939 MGI: 1919792 HomoloGene: 14597 GeneCards: PGAM5
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.33 Start 132,710,819 bp[1] End 132,722,734 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 110,259,130 bp[2] End 110,269,913 bp[2]
Gene ontology Molecular function • phosphatase activity • phosphoprotein phosphatase activity • hydrolase activity • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • GO:0001948 protein binding • GO:0032403 macromolecular complex binding • protein serine/threonine phosphatase activity Cellular component • integral component of membrane • membrane • mitochondrion • mitochondrial outer membrane Biological process • protein dephosphorylation • GO:0060554, GO:0060555 necroptosis • programmed cell death • dephosphorylation • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • macroautophagy • negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	192111	72542
Ensembl	ENSG00000247077	ENSMUSG00000029500
UniProt	Q96HS1	Q8BX10
RefSeq (mRNA)	NM_138575 NM_001170543 NM_001170544	NM_001163538 NM_028273
RefSeq (protein)	NP_001164014 NP_001164015 NP_612642	NP_001157010 NP_082549
Location (UCSC)	Chr 12: 132.71 – 132.72 Mb	Chr 5: 110.26 – 110.27 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Serine/threonine-protein phosphatase PGAM5, mitochondrial

PGAM family member 5, mitochondrial serine/threonine protein phosphatase
Identifiers
Symbol	PGAM5
NCBI gene	192111
PDB	5MUF
UniProt	Q96HS1
Other data
Locus	Chr. 12 q

1. GRCh38: Ensembl release 89: ENSG00000247077 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029500 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PGAM5, PGAM family member 5".
6. "UniProtKB: Q96HS1".