PEX11B

Peroxisomal membrane protein 11B is a protein that in humans is encoded by the PEX11B gene.[5][6] It is involved in the regulation of peroxisome abundance. [7]

PEX11B
Identifiers
Aliases	PEX11B, PEX11-BETA, PEX14B, peroxisomal biogenesis factor 11 beta
External IDs	OMIM: 603867 MGI: 1338882 HomoloGene: 2852 GeneCards: PEX11B
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.1 Start 145,911,350 bp[1] End 145,918,717 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 96,635,376 bp[2] End 96,645,366 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • protein homodimerization activity Cellular component • integral component of membrane • peroxisomal membrane • peroxisome • extracellular exosome • membrane • integral component of peroxisomal membrane • mitochondrion • macromolecular complex Biological process • regulation of peroxisome size • peroxisome organization • protein homooligomerization • signal transduction • peroxisome fission Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8799	18632
Ensembl	ENSG00000131779	ENSMUSG00000028102
UniProt	O96011	Q9Z210
RefSeq (mRNA)	NM_001184795 NM_003846	NM_001162387 NM_001162388 NM_011069
RefSeq (protein)	NP_001171724 NP_003837	NP_001155859 NP_001155860 NP_035199
Location (UCSC)	Chr 1: 145.91 – 145.92 Mb	Chr 3: 96.64 – 96.65 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PEX11B has been shown to interact with PEX19.[8][9]

Related gene problems

• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

References

1. GRCh38: Ensembl release 89: ENSG00000131779 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028102 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA, Gould SJ (December 1998). "Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli". J Biol Chem. 273 (45): 29607–14. doi:10.1074/jbc.273.45.29607. PMID 9792670.
6. "Entrez Gene: PEX11B peroxisomal biogenesis factor 11B".
7. Thoms S, Erdmann R (October 2005). "Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation". FEBS J. 272 (20): 5169–81. doi:10.1111/j.1742-4658.2005.04939.x. PMID 16218949.
8. Sacksteder, K A; Jones J M; South S T; Li X; Liu Y; Gould S J (March 2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. ISSN 0021-9525. PMC 2174547. PMID 10704444.
9. Fransen, M; Wylin T; Brees C; Mannaerts G P; Van Veldhoven P P (July 2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN 0270-7306. PMC 87101. PMID 11390669.

Further reading

• Abe I, Fujiki Y (1998). "cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p". Biochem. Biophys. Res. Commun. 252 (2): 529–33. doi:10.1006/bbrc.1998.9684. PMID 9826565.
• Sacksteder KA, Jones JM, South ST, et al. (2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
• Fransen M, Brees C, Ghys K, et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Mol. Cell. Proteomics. 1 (3): 243–52. doi:10.1074/mcp.M100025-MCP200. PMID 12096124.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Li X, Gould SJ (2003). "The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11". J. Biol. Chem. 278 (19): 17012–20. doi:10.1074/jbc.M212031200. PMID 12618434.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kobayashi S, Tanaka A, Fujiki Y (2007). "Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis". Exp. Cell Res. 313 (8): 1675–86. doi:10.1016/j.yexcr.2007.02.028. PMID 17408615.