PECR

Peroxisomal trans-2-enoyl-CoA reductase is an enzyme that in humans is encoded by the PECR gene.[5][6][7][8]

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PECR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YXM
Identifiers
Aliases	PECR, DCRRP, HPDHASE, HSA250303, PVIARL, SDR29C1, TERP, peroxisomal trans-2-enoyl-CoA reductase
External IDs	OMIM: 605843 MGI: 2148199 HomoloGene: 69255 GeneCards: PECR
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 215,996,329 bp[1] End 216,082,955 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C3|1 36.46 cM Start 72,259,167 bp[2] End 72,284,314 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • oxidoreductase activity • receptor binding • 2,4-dienoyl-CoA reductase (NADPH) activity • trans-2-enoyl-CoA reductase (NADPH) activity Cellular component • peroxisome • mitochondrion • peroxisomal membrane • cytosol Biological process • phytol metabolic process • fatty acid biosynthetic process • oxidation-reduction process • fatty acid metabolic process • lipid metabolism • fatty acid alpha-oxidation • protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55825	111175
Ensembl	ENSG00000115425	ENSMUSG00000026189
UniProt	Q9BY49	Q99MZ7
RefSeq (mRNA)	NM_018441	NM_023523 NM_001356516
RefSeq (protein)	NP_060911	NP_076012 NP_001343445
Location (UCSC)	Chr 2: 216 – 216.08 Mb	Chr 1: 72.26 – 72.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000115425 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026189 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Das AK, Uhler MD, Hajra AK (Sep 2000). "Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs". J Biol Chem. 275 (32): 24333–40. doi:10.1074/jbc.M001168200. PMID 10811639.
6. Amery L, Mannaerts GP, Subramani S, Van Veldhoven PP, Fransen M (Oct 2001). "Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology". Comb Chem High Throughput Screen. 4 (7): 545–52. doi:10.2174/1386207013330832. PMID 11669066.
7. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
8. "Entrez Gene: PECR peroxisomal trans-2-enoyl-CoA reductase".

Further reading

• Gay F, Anglade I, Gong Z, Salbert G (2001). "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions". Mol. Endocrinol. 14 (10): 1627–48. doi:10.1210/me.14.10.1627. PMID 11043578.
• Jia L, Young MF, Powell J, et al. (2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.
• Braastad CD, Leguia M, Hendrickson EA (2002). "Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element". Nucleic Acids Res. 30 (8): 1713–24. doi:10.1093/nar/30.8.1713. PMC 113227. PMID 11937624.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Gloerich J, Ruiter JP, van den Brink DM, et al. (2006). "Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation". FEBS Lett. 580 (8): 2092–6. doi:10.1016/j.febslet.2006.03.011. PMID 16546181.