PDE2A

cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.[4][5]

PDE2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z1L, 3IBJ, 3ITM, 3ITU, 4C1I, 4D08, 4D09, 4HTX, 4HTZ, 4JIB
Identifiers
Aliases	PDE2A, CGS-PDE, PDE2A1, PED2A4, cGSPDE, phosphodiesterase 2A
External IDs	OMIM: 602658 MGI: 2446107 HomoloGene: 1952 GeneCards: PDE2A
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 72,576,141 bp[1] End 72,674,591 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • 3',5'-cyclic-nucleotide phosphodiesterase activity • calcium channel activity • cGMP binding • metal ion binding • cyclic-nucleotide phosphodiesterase activity • GO:0001948 protein binding • drug binding • phosphoric diester hydrolase activity • TPR domain binding • hydrolase activity • cGMP-stimulated cyclic-nucleotide phosphodiesterase activity • cAMP binding • protein homodimerization activity • 3',5'-cyclic-AMP phosphodiesterase activity • 3',5'-cyclic-GMP phosphodiesterase activity • identical protein binding • magnesium ion binding • zinc ion binding • phosphate ion binding Cellular component • cytoplasm • cytosol • Golgi apparatus • membrane • cell membrane • endoplasmic reticulum • mitochondrion • perinuclear region of cytoplasm • presynaptic membrane • cell nucleus • mitochondrial outer membrane • mitochondrial inner membrane • mitochondrial matrix Biological process • establishment of endothelial barrier • cellular response to transforming growth factor beta stimulus • positive regulation of inflammatory response • cellular response to cGMP • negative regulation of transcription from RNA polymerase II promoter • monocyte differentiation • cGMP-mediated signaling • cellular response to macrophage colony-stimulating factor stimulus • cellular response to mechanical stimulus • cellular response to drug • positive regulation of vascular permeability • cellular response to granulocyte macrophage colony-stimulating factor stimulus • cAMP-mediated signaling • signal transduction • negative regulation of vascular permeability • cGMP catabolic process • cAMP catabolic process • calcium ion transmembrane transport • G-protein coupled receptor signaling pathway • negative regulation of cAMP-mediated signaling • cellular response to cAMP • cellular response to 2,3,7,8-tetrachlorodibenzodioxine • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • positive regulation of gene expression • negative regulation of cGMP-mediated signaling • regulation of mitochondrion organization • heart valve development • ventricular septum development • aorta development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5138	207728
Ensembl	ENSG00000186642	ENSMUSG00000030653
UniProt	O00408	Q922S4
RefSeq (mRNA)	NM_001143839 NM_001146209 NM_001243784 NM_002599	NM_001008548 NM_001143848 NM_001143849 NM_001243757 NM_001243758
RefSeq (protein)	NP_001137311 NP_001139681 NP_001230713 NP_002590	NP_001008548 NP_001137320 NP_001137321 NP_001230686 NP_001230687
Location (UCSC)	Chr 11: 72.58 – 72.67 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000186642 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Rosman GJ, Martins TJ, Sonnenburg WK, Beavo JA, Ferguson K, Loughney K (Aug 1997). "Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase". Gene. 191 (1): 89–95. doi:10.1016/S0378-1119(97)00046-2. PMID 9210593.
5. "Entrez Gene: PDE2A phosphodiesterase 2A, cGMP-stimulated".

Further reading

• Witzenrath M, Gutbier B, Schmeck B, et al. (2005). "Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia". Critical Care Medicine. 37 (9): 584–590. doi:10.1097/CCM.0b013e3181959814. PMID 19114892.
• Seybold J, Thomas D, Witzenrath M, et al. (2009). "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability". Blood. 105 (9): 3569–3576. doi:10.1182/blood-2004-07-2729. PMID 15650061.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Martinez SE, Wu AY, Glavas NA, et al. (2002). "The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13260–13265. doi:10.1073/pnas.192374899. PMC 130621. PMID 12271124.
• Manns JM, Brenna KJ, Colman RW, Sheth SB (2002). "Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases". Thromb. Haemost. 87 (5): 873–9. PMID 12038792.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–491. doi:10.1096/fj.00-0354com. PMID 11156964.
• Sadhu K, Hensley K, Florio VA, Wolda SL (1999). "Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells". J. Histochem. Cytochem. 47 (7): 895–906. doi:10.1177/002215549904700707. PMID 10375378.