PDE1B

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B is an enzyme that in humans is encoded by the PDE1B gene.[5][6][7]

PDE1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TAZ, 4NPV, 4NPW, 5B25
Identifiers
Aliases	PDE1B, PDE1B1, PDES1B, HEL-S-79p, phosphodiesterase 1B
External IDs	OMIM: 171891 MGI: 97523 HomoloGene: 37370 GeneCards: PDE1B
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 54,549,601 bp[1] End 54,579,239 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F3 Start 103,503,034 bp[2] End 103,530,052 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • 3',5'-cyclic-nucleotide phosphodiesterase activity • metal ion binding • calmodulin binding • cyclic-nucleotide phosphodiesterase activity • calmodulin-dependent cyclic-nucleotide phosphodiesterase activity • GO:0001948 protein binding • phosphoric diester hydrolase activity • hydrolase activity • calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity • 3',5'-cyclic-AMP phosphodiesterase activity • 3',5'-cyclic-GMP phosphodiesterase activity Cellular component • cytoplasm • neuronal cell body • cytosol Biological process • visual learning • regulation of neurotransmitter levels • cAMP catabolic process • locomotory behavior • response to amphetamine • serotonin metabolic process • monocyte differentiation • regulation of dopamine metabolic process • cellular response to macrophage colony-stimulating factor stimulus • cGMP catabolic process • cellular response to granulocyte macrophage colony-stimulating factor stimulus • apoptotic process • signal transduction • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5153	18574
Ensembl	ENSG00000123360	ENSMUSG00000022489
UniProt	Q01064	Q01065
RefSeq (mRNA)	NM_000924 NM_001165975 NM_001288768 NM_001288769 NM_001315534 NM_001315535	NM_001285890 NM_008800 NM_001357980
RefSeq (protein)	NP_000915 NP_001159447 NP_001275697 NP_001275698 NP_001302463 NP_001302464	NP_001272819 NP_032826 NP_001344909
Location (UCSC)	Chr 12: 54.55 – 54.58 Mb	Chr 15: 103.5 – 103.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000123360 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022489 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jiang X, Li J, Paskind M, Epstein PM (Nov 1996). "Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells". Proc Natl Acad Sci U S A. 93 (20): 11236–41. doi:10.1073/pnas.93.20.11236. PMC 1074519. PMID 8855339.
6. Yu J, Wolda SL, Frazier AL, Florio VA, Martins TJ, Snyder PB, Harris EA, McCaw KN, Farrell CA, Steiner B, Bentley JK, Beavo JA, Ferguson K, Gelinas R (Feb 1998). "Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1". Cell Signal. 9 (7): 519–29. doi:10.1016/S0898-6568(97)00046-6. PMID 9419816.
7. "Entrez Gene: PDE1B phosphodiesterase 1B, calmodulin-dependent".

Further reading

• Repaske DR, Swinnen JV, Jin SL, et al. (1992). "A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase". J. Biol. Chem. 267 (26): 18683–8. PMID 1326532.
• Spence S, Rena G, Sullivan M, et al. (1997). "Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase". Biochem. J. 321 ( Pt 1) (Pt 1): 157–63. doi:10.1042/bj3210157. PMC 1218050. PMID 9003415.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.
• Fidock M, Miller M, Lanfear J (2002). "Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants". Cell. Signal. 14 (1): 53–60. doi:10.1016/S0898-6568(01)00207-8. PMID 11747989.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bender AT, Ostenson CL, Wang EH, Beavo JA (2005). "Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation". Proc. Natl. Acad. Sci. U.S.A. 102 (2): 497–502. doi:10.1073/pnas.0408535102. PMC 544304. PMID 15625104.
• Bender AT, Beavo JA (2006). "PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte". Proc. Natl. Acad. Sci. U.S.A. 103 (2): 460–5. doi:10.1073/pnas.0509972102. PMC 1326187. PMID 16407168.