PCDH10

Protocadherin-10 is a protein that in humans is encoded by the PCDH10 gene.[5][6]

PCDH10
Identifiers
Aliases	PCDH10, OL-PCDH, PCDH19, protocadherin 10
External IDs	OMIM: 608286 MGI: 1338042 HomoloGene: 74967 GeneCards: PCDH10
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q28.3 Start 133,149,294 bp[1] End 133,208,606 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 B Start 45,378,398 bp[2] End 45,435,623 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane Biological process • homophilic cell adhesion via plasma membrane adhesion molecules • cell adhesion • cell-cell signaling • nervous system development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57575	18526
Ensembl	ENSG00000138650	ENSMUSG00000049100
UniProt	Q9P2E7	n/a
RefSeq (mRNA)	NM_020815 NM_032961	NM_001098170 NM_001098171 NM_001098172 NM_011043
RefSeq (protein)	NP_065866 NP_116586	n/a
Location (UCSC)	Chr 4: 133.15 – 133.21 Mb	Chr 3: 45.38 – 45.44 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The mRNA encodes a cadherin-related neuronal receptor thought to play a role in the establishment and function of specific cell-cell connections in the brain. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Alternatively spliced transcripts encode isoforms with unique cytoplasmic domains.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000138650 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049100 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
6. "Entrez Gene: PCDH10 protocadherin 10".

Further reading

• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752.
• Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.
• Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Wu Q, Zhang T, Cheng JF, et al. (2001). "Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters". Genome Res. 11 (3): 389–404. doi:10.1101/gr.167301. PMC 311048. PMID 11230163.
• Wolverton T, Lalande M (2001). "Identification and characterization of three members of a novel subclass of protocadherins". Genomics. 76 (1–3): 66–72. doi:10.1006/geno.2001.6592. PMID 11549318.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ying J, Li H, Seng TJ, et al. (2006). "Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation". Oncogene. 25 (7): 1070–80. doi:10.1038/sj.onc.1209154. PMID 16247458.