PAPPA2

Pappalysin-2 is a protein that in humans is encoded by the PAPPA2 gene.[5][6][7]

PAPPA2
Identifiers
Aliases	PAPPA2, PAPP-A2, PAPP-E, PAPPE, PLAC3, pappalysin 2
External IDs	MGI: 3051647 HomoloGene: 10661 GeneCards: PAPPA2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.2 Start 176,463,171 bp[1] End 176,845,601 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H1 Start 158,711,727 bp[2] End 158,980,490 bp[2]
Gene ontology Molecular function • zinc ion binding • peptidase activity • hydrolase activity • metallopeptidase activity • metal ion binding • metalloendopeptidase activity Cellular component • extracellular region • extracellular exosome • intracellular • cytosol • apical plasma membrane Biological process • cellular protein metabolic process • bone morphogenesis • regulation of cell growth • proteolysis • response to salt stress Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	60676	23850
Ensembl	ENSG00000116183	ENSMUSG00000073530
UniProt	Q9BXP8	n/a
RefSeq (mRNA)	NM_020318 NM_021936	NM_001085376
RefSeq (protein)	NP_064714 NP_068755	n/a
Location (UCSC)	Chr 1: 176.46 – 176.85 Mb	Chr 1: 158.71 – 158.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000116183 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073530 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H (Nov 2000). "Pregnancy-associated plasma protein-E (PAPP-E)". Biochim Biophys Acta. 1493 (3): 356–62. doi:10.1016/s0167-4781(00)00195-0. PMID 11018262.
6. Overgaard MT, Boldt HB, Laursen LS, Sottrup-Jensen L, Conover CA, Oxvig C (Jun 2001). "Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase". J Biol Chem. 276 (24): 21849–53. doi:10.1074/jbc.M102191200. PMID 11264294.
7. "Entrez Gene: PAPPA2 pappalysin 2".

Further reading

• Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins". Endocr. Rev. 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (2001). "The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant". Placenta. 22 (8–9): 681–7. doi:10.1053/plac.2001.0709. PMID 11597188.
• Ständker L, Wobst P, Mark S, Forssmann WG (1999). "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5". FEBS Lett. 441 (2): 281–6. doi:10.1016/S0014-5793(98)01497-5. PMID 9883900.