PAOX

Peroxisomal N(1)-acetyl-spermine/spermidine oxidase is an enzyme that in humans is encoded by the PAOX gene.[5][6]

PAOX
Identifiers
Aliases	PAOX, PAO, polyamine oxidase (exo-N4-amino), polyamine oxidase
External IDs	OMIM: 615853 MGI: 1916983 HomoloGene: 72096 GeneCards: PAOX
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.3 Start 133,379,261 bp[1] End 133,391,694 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F4 Start 140,115,799 bp[2] End 140,137,224 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • polyamine oxidase activity • N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity • N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity • spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity • spermine:oxygen oxidoreductase (spermidine-forming) activity • N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity • oxidoreductase activity • receptor binding Cellular component • cytoplasm • peroxisome • peroxisomal matrix • cytosol Biological process • spermine metabolic process • spermine catabolic process • spermidine catabolic process • positive regulation of spermidine biosynthetic process • polyamine biosynthetic process • putrescine biosynthetic process • polyamine catabolic process • oxidation-reduction process • putrescine catabolic process • protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	196743	212503
Ensembl	ENSG00000148832	ENSMUSG00000025464
UniProt	Q6QHF9	Q8C0L6
RefSeq (mRNA)	NM_152911 NM_207125 NM_207126 NM_207127 NM_207128 NM_207129	NM_153783 NM_001346725
RefSeq (protein)	NP_690875 NP_997010 NP_997011	NP_001333654 NP_722478
Location (UCSC)	Chr 10: 133.38 – 133.39 Mb	Chr 7: 140.12 – 140.14 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000148832 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025464 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wu T, Yankovskaya V, McIntire WS (Jun 2003). "Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase". J Biol Chem. 278 (23): 20514–20525. doi:10.1074/jbc.M302149200. PMID 12660232.
6. "Entrez Gene: PAOX polyamine oxidase (exo-N4-amino)".

Further reading

• Järvinen A, Keinänen TA, Grigorenko NA, et al. (2006). "Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase". J. Biol. Chem. 281 (8): 4589–4595. doi:10.1074/jbc.M509959200. PMID 16354669.
• Pledgie A, Huang Y, Hacker A, et al. (2006). "Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines". J. Biol. Chem. 280 (48): 39843–39851. doi:10.1074/jbc.M508177200. PMID 16207710.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Vujcic S, Liang P, Diegelman P, et al. (2003). "Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion". Biochem. J. 370 (Pt 1): 19–28. doi:10.1042/BJ20021779. PMC 1223169. PMID 12477380.