PABPC5

Poly(A) binding protein cytoplasmic 5 is a protein that in humans is encoded by the PABPC5 gene. [4]

PABPC5
Identifiers
Aliases	PABPC5, PABP5, poly(A) binding protein cytoplasmic 5
External IDs	OMIM: 300407 MGI: 2136401 HomoloGene: 5857 GeneCards: PABPC5
Gene location (Human) Chr. X chromosome (human)[1] Band Xq21.31 Start 91,434,595 bp[1] End 91,438,584 bp[1]
Orthologs
Species	Human	Mouse
Entrez	140886	93728
Ensembl	ENSG00000174740	n/a
UniProt	Q96DU9	Q8C7D3
RefSeq (mRNA)	NM_080832	NM_053114
RefSeq (protein)	NP_543022	NP_444344
Location (UCSC)	Chr X: 91.43 – 91.44 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a poly(A)-binding protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. [provided by RefSeq, May 2010].

References

1. GRCh38: Ensembl release 89: ENSG00000174740 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: Poly(A) binding protein cytoplasmic 5". Retrieved 2020-04-16.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.