P87PIKAP
p87PIKAP is a regulatory subunit of the type IB Phosphoinositide 3-Kinase p110γ that is highly expressed in the heart and is present in dendritic cells, macrophages, and neutrophils.[1] It is also referred to as p84 and p87.[2] Some studies have found P87PIKAP to have a role in carcinogenesis.[3]
| Phosphoinositide-3-kinase adapter protein of 87 kDa | |
|---|---|
| Identifiers | |
| Symbol | p87PIKAP |
| Alt. symbols | p84,PIK3R6 |
| NCBI gene | 146850 |
| HGNC | 27101 |
| OMIM | 611462 |
| UniProt | Q5UE93 |
| Other data | |
| Locus | Chr. 17 p13.1 |
References
- Voigt P, Dorner MB, Schaefer M (2006). "Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B". The Journal of Biological Chemistry. 281 (15): 9977–86. doi:10.1074/jbc.M512502200. PMID 16476736.
- Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, et al. (2009). "Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma". Proceedings of the National Academy of Sciences of the United States of America. 106 (48): 20312–7. doi:10.1073/pnas.0905506106. PMC 2787109. PMID 19906996.
- Brazzatti, JA; et al. (2012). "Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis" (PDF). Oncogene. 31 (18): 2350–2361. doi:10.1038/onc.2011.414. PMID 21996737.
The context of the function of p87.
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