P53AIP1

p53-regulated apoptosis-inducing protein 1 is a protein that in humans is encoded by the TP53AIP1 gene.[3][4][5]

TP53AIP1
Identifiers
Aliases	TP53AIP1, P53AIP1, tumor protein p53 regulated apoptosis inducing protein 1
External IDs	OMIM: 605426 HomoloGene: 137360 GeneCards: TP53AIP1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q24.3 Start 128,934,731 bp[1] End 128,943,399 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • molecular function Cellular component • mitochondrion • mitochondrial matrix Biological process • apoptotic process • regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	63970	n/a
Ensembl	ENSG00000120471	n/a
UniProt	Q9HCN2	n/a
RefSeq (mRNA)	NM_022112 NM_001195194 NM_001195195 NM_001251964	n/a
RefSeq (protein)	NP_001182123 NP_001182124 NP_001238893 NP_071395	n/a
Location (UCSC)	Chr 11: 128.93 – 128.94 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000120471 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y, Taya Y (Oct 2000). "p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53". Cell. 102 (6): 849–62. doi:10.1016/S0092-8674(00)00073-8. PMID 11030628.
4. Matsuda K, Yoshida K, Taya Y, Nakamura K, Nakamura Y, Arakawa H (May 2002). "p53AIP1 regulates the mitochondrial apoptotic pathway". Cancer Res. 62 (10): 2883–9. PMID 12019168.
5. "Entrez Gene: P53AIP1 p53-regulated apoptosis-inducing protein 1".

Further reading

• Strano S, Monti O, Pediconi N, et al. (2005). "The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage". Mol. Cell. 18 (4): 447–59. doi:10.1016/j.molcel.2005.04.008. PMID 15893728.
• Wesierska-Gadek J, Gueorguieva M, Horky M (2005). "Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells". Mol. Cancer Ther. 4 (1): 113–24. PMID 15657359.
• Chan KT, Lung ML (2004). "Mutant p53 expression enhances drug resistance in a hepatocellular carcinoma cell line". Cancer Chemother. Pharmacol. 53 (6): 519–26. doi:10.1007/s00280-004-0767-4. PMID 15004724.
• Kövesi G, Szende B (2004). "Changes in apoptosis and mitotic index, p53 and Ki67 expression in various types of oral leukoplakia". Oncology. 65 (4): 331–6. doi:10.1159/000074646. PMID 14707453.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.