Oxycyte

Oxycyte is an experimental third-generation perfluorocarbon (PFC) therapeutic oxygen carrier invented by Leland Clark and developed by Tenax Therapeutics (TENX; formerly Oxygen Biotherapeutics, Inc. and Synthetic Blood International).[1] It is designed to enhance oxygen delivery to damaged tissues. Through a collaborative agreement, Oxycyte (under the development code name of ABL-101) is now being developed by Aurum Biosciences Ltd, with an initial indication in acute ischemic stroke.[2]

Product

When used as an intravenous emulsion, Oxycyte can carry as much as five times more oxygen than hemoglobin, making it an effective means of transporting oxygen to tissues and carrying carbon dioxide to the lungs for disposal.[3] Like all PFC-based products, Oxycyte is not a complete blood substitute.

Because Oxycyte is a PFC, and not based on hemoglobin, it does not have the safety issues associated with hemoglobin-based products; there have been no adverse events in company clinical trials that were related to Oxycyte. Tenax believes that Oxycyte has a very favorable risk-benefit profile for its potential indications.

Aurum Biosciences has received Wellcome Trust HICF funding to take Oxycyte into a phase IIa clinical trial in stroke patients. This work will investigate both therapeutic potential and its ability to enhance the diagnostic potential of MRI in stroke.[4][5][6]

Aurum Biosciences promotes Oxycyte as having potential for use in multiple indications, including cardiology, oncology, epilepsy and neuro-degenerative diseases.

Oxygen Biotherapeutics announced in September, 2014, that it would discontinue a Phase IIb trial for its Oxycte drug candidate.[7]

Chemical properties

The active chemical substance in Oxycyte is Perfluoro (tert-butylcyclohexane), a saturated alicyctic PFC (molecular formula C10F20).[8][9]

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References
  1. "Oxycyte | Tenax Therapeutics". www.tenaxthera.com. Retrieved 2017-01-24.
  2. "Aurum Biosciences". www.aurumbiosciences.com. Retrieved 2017-01-24.
  3. Oxygen Biotherapeutics, Inc. Corporate website.
  4. "Health Innovation Challenge Fund: projects we've funded | Wellcome". wellcome.ac.uk. Retrieved 2017-01-24.
  5. "Technology and Products – Aurum Biosciences". www.aurumbiosciences.com. Retrieved 2017-01-24.
  6. , Santosh, Celestine & David Brennan, "Method of imaging metabolic function"
  7. "Oxygen Biotherapeutics Announces Halt of Oxycyte Phase IIb Traumatic Brain Injury Trial". businesswire.com. September 11, 2014.
  8. Winslow, Robert M. (2006). Blood Substitutes. Academic Press. p. 303. ISBN 978-0127597607.
  9. US application 12/460,409 M. Ross Bullock et al, filing date July 17, 2009
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