Otu deubiquitinase 5

OTU deubiquitinase 5 is a protein that in humans is encoded by the OTUD5 gene. [3]

OTUD5
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3PFY, 3TMO, 3TMP
Identifiers
Aliases	OTUD5, DUBA, OTU deubiquitinase 5
External IDs	OMIM: 300713 HomoloGene: 136483 GeneCards: OTUD5
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.23 Start 48,922,028 bp[1] End 48,958,386 bp[1]
Gene ontology Molecular function • thiol-dependent ubiquitinyl hydrolase activity • peptidase activity • cysteine-type peptidase activity • hydrolase activity • thiol-dependent ubiquitin-specific protease activity • Lys63-specific deubiquitinase activity • GO:1904265 ubiquitinyl hydrolase activity • Lys48-specific deubiquitinase activity Cellular component • cytosol Biological process • negative regulation of type I interferon production • response to lipopolysaccharide • protein K63-linked deubiquitination • protein K48-linked deubiquitination • proteolysis • protein deubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55593	n/a
Ensembl	ENSG00000068308	n/a
UniProt	Q96G74	n/a
RefSeq (mRNA)	NM_001136157 NM_001136158 NM_001136159 NM_017602	n/a
RefSeq (protein)	NP_001129629 NP_001129630 NP_001129631 NP_060072	n/a
Location (UCSC)	Chr X: 48.92 – 48.96 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.

References

1. GRCh38: Ensembl release 89: ENSG00000068308 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: OTU deubiquitinase 5". Retrieved 2017-03-25.

Further reading

• Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM (2007). "DUBA: a deubiquitinase that regulates type I interferon production". Science. 318 (5856): 1628–32. doi:10.1126/science.1145918. PMID 17991829.
• Huang OW, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, Phung Q, Bosanac I, Arnott D, Dixit VM, Hymowitz SG, Starovasnik MA, Cochran AG (2012). "Phosphorylation-dependent activity of the deubiquitinase DUBA". Nat. Struct. Mol. Biol. 19 (2): 171–5. doi:10.1038/nsmb.2206. PMID 22245969.
• Luo J, Lu Z, Lu X, Chen L, Cao J, Zhang S, Ling Y, Zhou X (2013). "OTUD5 regulates p53 stability by deubiquitinating p53". PLoS ONE. 8 (10): e77682. doi:10.1371/journal.pone.0077682. PMC 3797110. PMID 24143256.

External links

• Overview of all the structural information available in the PDB for UniProt: Q96G74 (Human OTU domain-containing protein 5) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.