Olfactomedin 1

Olfactomedin 1, also known as noelin 1 or pancortin, is a protein that in humans is encoded by the OLFM1 gene.[5][6] The name noelin stands for "neuronal olfactomedin-related endoplasmic reticulum-localized 1".[7]

OLFM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XAT
Identifiers
Aliases	OLFM1, AMY, NOE1, NOELIN1, OlfA, olfactomedin 1
External IDs	OMIM: 605366 MGI: 1860437 HomoloGene: 8612 GeneCards: OLFM1
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 135,075,422 bp[1] End 135,121,179 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 28,192,992 bp[2] End 28,230,736 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • extracellular region • cell junction • axon • neuronal cell body • perikaryon • axonal growth cone • synapse • cell projection • cell • endoplasmic reticulum • extracellular Biological process • multicellular organism development • atrioventricular valve formation • neuronal signal transduction • positive regulation of gene expression • regulation of axon extension • positive regulation of epithelial to mesenchymal transition • negative regulation of gene expression • nervous system development • cardiac epithelial to mesenchymal transition • positive regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10439	56177
Ensembl	ENSG00000130558	ENSMUSG00000026833
UniProt	Q99784	O88998
RefSeq (mRNA)	NM_058199 NM_001282611 NM_001282612 NM_006334 NM_014279	NM_001038612 NM_001038613 NM_001038614 NM_019498
RefSeq (protein)	NP_001269540 NP_001269541 NP_006325 NP_055094	NP_001033701 NP_001033702 NP_001033703 NP_062371
Location (UCSC)	Chr 9: 135.08 – 135.12 Mb	Chr 2: 28.19 – 28.23 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.[6]

Cancer

OLFM1 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.[8] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000130558 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026833 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yokoyama M, Nishi Y, Yoshii J, Okubo K, Matsubara K (May 1997). "Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles". DNA Res. 3 (5): 311–20. doi:10.1093/dnares/3.5.311. PMID 9039501.
6. "Entrez Gene: OLFM1 olfactomedin 1".
7. Anholt, Robert R. H. (2014). "Olfactomedin proteins: central players in development and disease". Frontiers in Cell and Developmental Biology. 2: 6. doi:10.3389/fcell.2014.00006. PMC 4206993. PMID 25364714.
8. Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. PMID 25205602.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Camargo LM, Collura V, Rain JC, et al. (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia". Mol. Psychiatry. 12 (1): 74–86. doi:10.1038/sj.mp.4001880. PMID 17043677.