OSTF1

Osteoclast-stimulating factor 1 is a protein that in humans is encoded by the OSTF1 gene.[5][6]

OSTF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X2K, 1ZLM, 3EHQ, 3EHR
Identifiers
Aliases	OSTF1, OSF, SH3P2, bA235O14.1, osteoclast stimulating factor 1
External IDs	OMIM: 610180 MGI: 700012 HomoloGene: 8227 GeneCards: OSTF1
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q21.13 Start 75,088,514 bp[1] End 75,147,265 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 B|19 13.17 cM Start 18,516,137 bp[2] End 18,631,823 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • SH3 domain binding • GO:0001948 protein binding Cellular component • cytoplasm • intracellular • secretory granule lumen • ficolin-1-rich granule lumen • extracellular region Biological process • ossification • signal transduction • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26578	20409
Ensembl	ENSG00000134996	ENSMUSG00000024725
UniProt	Q92882	Q62422
RefSeq (mRNA)	NM_012383	NM_017375
RefSeq (protein)	NP_036515	NP_059071
Location (UCSC)	Chr 9: 75.09 – 75.15 Mb	Chr 19: 18.52 – 18.63 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000134996 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024725 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reddy S, Devlin R, Menaa C, Nishimura R, Choi SJ, Dallas M, Yoneda T, Roodman GD (Apr 1999). "Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption". J Cell Physiol. 177 (4): 636–45. doi:10.1002/(SICI)1097-4652(199812)177:4<636::AID-JCP14>3.0.CO;2-H. PMID 10092216.
6. "Entrez Gene: OSTF1 osteoclast stimulating factor 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Sparks AB, Hoffman NG, McConnell SJ, et al. (1998). "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins". Nat. Biotechnol. 14 (6): 741–4. doi:10.1038/nbt0696-741. PMID 9630982.
• Schaub R, Dupont B, Roodman GD, et al. (2000). "Assignment of OSTF1 to human chromosome bands 12q24.1→q24.2 by in situ hybridization". Cytogenet. Cell Genet. 88 (1–2): 87–8. doi:10.1159/000015492. PMID 10773673.
• Kurihara N, Menaa C, Maeda H, et al. (2001). "Osteoclast-stimulating factor interacts with the spinal muscular atrophy gene product to stimulate osteoclast formation". J. Biol. Chem. 276 (44): 41035–9. doi:10.1074/jbc.M100233200. PMID 11551898.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Szymkiewicz I, Destaing O, Jurdic P, Dikic I (2004). "SH3P2 in complex with Cbl and Src". FEBS Lett. 565 (1–3): 33–8. doi:10.1016/j.febslet.2004.03.100. PMID 15135048.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Li M, Meng Z, Xu Y, et al. (2006). "Crystallization and preliminary X-ray crystallographic analysis of osteoclast-stimulating factor". Acta Crystallographica Section F. 61 (Pt 1): 128–30. doi:10.1107/S1744309104031653. PMC 1952375. PMID 16508112.
• Chen L, Wang Y, Wells D, et al. (2006). "Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution". Acta Crystallographica Section F. 62 (Pt 9): 844–8. doi:10.1107/S1744309106030004. PMC 2242886. PMID 16946461.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.