OSR2 (gene)

Protein odd-skipped-related 2 is a protein that in humans is encoded by the OSR2 gene.[5] In mice, it is involved in the development of the palate and in suppressing the formation of teeth after the eruption of adult teeth.

OSR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EE8
Identifiers
Aliases	OSR2, odd-skipped related transciption factor 2
External IDs	OMIM: 611297 MGI: 1930813 HomoloGene: 14200 GeneCards: OSR2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.2 Start 98,944,403 bp[1] End 98,952,104 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 B3.1|15 14.46 cM Start 35,296,098 bp[2] End 35,303,305 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • GO:0001948 protein binding • nucleic acid binding • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II regulatory region sequence-specific DNA binding Cellular component • cell nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • metanephros development • mesonephros development • chondrocyte differentiation • positive regulation of cell proliferation • positive regulation of gene expression • cell differentiation • positive regulation of bone mineralization • osteoblast proliferation • embryonic forelimb morphogenesis • embryonic hindlimb morphogenesis • embryonic skeletal limb joint morphogenesis • middle ear morphogenesis • odontogenesis • embryonic digit morphogenesis • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • embryonic skeletal system morphogenesis • positive regulation of epithelial cell proliferation • palate development • embryonic skeletal joint morphogenesis • head development • bone morphogenesis • eyelid development in camera-type eye • embryonic skeletal joint development • embryo development ending in birth or egg hatching • urogenital system development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116039	107587
Ensembl	ENSG00000164920	ENSMUSG00000022330
UniProt	Q8N2R0	Q91ZD1
RefSeq (mRNA)	NM_001142462 NM_001286841 NM_053001	NM_054049 NM_001368665
RefSeq (protein)	NP_001135934 NP_001273770 NP_443727	NP_473390 NP_001355594
Location (UCSC)	Chr 8: 98.94 – 98.95 Mb	Chr 15: 35.3 – 35.3 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000164920 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022330 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OSR2 odd-skipped related 2 (Drosophila)".

Further reading

• Kawai S, Kato T, Inaba H, et al. (2005). "Odd-skipped related 2 splicing variants show opposite transcriptional activity". Biochem. Biophys. Res. Commun. 328 (1): 306–11. doi:10.1016/j.bbrc.2004.12.173. PMID 15670784.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lan Y, Ovitt CE, Cho ES, et al. (2004). "Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis". Development. 131 (13): 3207–16. doi:10.1242/dev.01175. PMID 15175245.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Katoh M (2003). "Molecular cloning and characterization of OSR1 on human chromosome 2p24". Int. J. Mol. Med. 10 (2): 221–5. doi:10.3892/ijmm.10.2.221. PMID 12119563.
• Lan Y, Kingsley PD, Cho ES, Jiang R (2001). "Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns during craniofacial, limb, and kidney development". Mech. Dev. 107 (1–2): 175–9. doi:10.1016/S0925-4773(01)00457-9. PMID 11520675.

See also

OSR1