OSCAR (gene)

Osteoclast-associated immunoglobulin-like receptor is a protein that in humans is encoded by the OSCAR gene.[5][6]

OSCAR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5EIV, 5EIQ, 5CJB, 5CJ8
Identifiers
Aliases	OSCAR, PIGR3, PIgR-3, osteoclast associated, immunoglobulin-like receptor, osteoclast associated Ig-like receptor
External IDs	OMIM: 606862 MGI: 2179720 HomoloGene: 77042 GeneCards: OSCAR
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,094,668 bp[1] End 54,102,692 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 3,609,813 bp[2] End 3,616,157 bp[2]
Gene ontology Molecular function • collagen receptor activity Cellular component • integral component of membrane • extracellular region • cell membrane • extracellular exosome • membrane • specific granule lumen • tertiary granule lumen Biological process • regulation of immune response • neutrophil degranulation • osteoclast differentiation • collagen-activated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	126014	232790
Ensembl	ENSG00000277088 ENSG00000170909 ENSG00000274703 ENSG00000276982 ENSG00000278533 ENSG00000275736 ENSG00000275551 ENSG00000278378 ENSG00000273511 ENSG00000275644	ENSMUSG00000054594
UniProt	Q8IYS5	Q8VBT3
RefSeq (mRNA)	NM_001282349 NM_001282350 NM_130771 NM_133168 NM_133169 NM_206817 NM_206818	NM_001290377 NM_175632
RefSeq (protein)	NP_001269278 NP_001269279 NP_570127 NP_573398 NP_573399 NP_996554	NP_001277306 NP_783440
Location (UCSC)	Chr 19: 54.09 – 54.1 Mb	Chr 7: 3.61 – 3.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[6]

References

1. ENSG00000170909, ENSG00000274703, ENSG00000276982, ENSG00000278533, ENSG00000275736, ENSG00000275551, ENSG00000278378, ENSG00000273511, ENSG00000275644 GRCh38: Ensembl release 89: ENSG00000277088, ENSG00000170909, ENSG00000274703, ENSG00000276982, ENSG00000278533, ENSG00000275736, ENSG00000275551, ENSG00000278378, ENSG00000273511, ENSG00000275644 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054594 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kim N, Takami M, Rho J, Josien R, Choi Y (Jan 2002). "A novel member of the leukocyte receptor complex regulates osteoclast differentiation". J Exp Med. 195 (2): 201–9. doi:10.1084/jem.20011681. PMC 2193610. PMID 11805147.
6. "Entrez Gene: OSCAR osteoclast-associated receptor".

Further reading

• Pupello DF, Lipton M, Shumway NE (1976). "An unusual case of a bullet embolus". The Journal of the Florida Medical Association. 62 (11): 51. PMID 1185147.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Merck E, Gaillard C, Gorman DM, et al. (2004). "OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells". Blood. 104 (5): 1386–95. doi:10.1182/blood-2004-03-0850. PMID 15155468.
• Merck E, de Saint-Vis B, Scuiller M, et al. (2005). "Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses". Blood. 105 (9): 3623–32. doi:10.1182/blood-2004-07-2809. PMID 15650060.
• Tenca C, Merlo A, Merck E, et al. (2005). "CD85j (leukocyte Ig-like receptor-1/Ig-like transcript 2) inhibits human osteoclast-associated receptor-mediated activation of human dendritic cells". J. Immunol. 174 (11): 6757–63. doi:10.4049/jimmunol.174.11.6757. PMID 15905516.
• Kim GS, Koh JM, Chang JS, et al. (2005). "Association of the OSCAR promoter polymorphism with BMD in postmenopausal women". J. Bone Miner. Res. 20 (8): 1342–8. doi:10.1359/JBMR.050320. PMID 16007331.
• Kim K, Kim JH, Lee J, et al. (2005). "Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis". J. Biol. Chem. 280 (42): 35209–16. doi:10.1074/jbc.M505815200. PMID 16109714.
• Merck E, Gaillard C, Scuiller M, et al. (2006). "Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils". J. Immunol. 176 (5): 3149–56. doi:10.4049/jimmunol.176.5.3149. PMID 16493074.