OSBPL5

Oxysterol-binding protein-related protein 5 is a protein that in humans is encoded by the OSBPL5 gene.[5]

OSBPL5
Identifiers
Aliases	OSBPL5, OBPH1, ORP5, oxysterol binding protein like 5
External IDs	OMIM: 606733 MGI: 1930265 HomoloGene: 98024 GeneCards: OSBPL5
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 3,087,107 bp[1] End 3,166,739 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 88.29 cM Start 143,688,762 bp[2] End 143,756,985 bp[2]
Gene ontology Molecular function • cholesterol binding • phosphatidylinositol-4-phosphate binding • oxysterol binding • phosphatidylserine binding • lipid binding • phospholipid transporter activity • sterol transporter activity • sterol binding Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum • cytosol • intracellular membrane-bounded organelle • endoplasmic reticulum-plasma membrane contact site Biological process • phospholipid transport • cholesterol transport • lipid transport • cholesterol metabolic process • Golgi to plasma membrane transport • phosphatidylserine acyl-chain remodeling • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114879	79196
Ensembl	ENSG00000021762	ENSMUSG00000037606
UniProt	Q9H0X9	Q9ER64
RefSeq (mRNA)	NM_001144063 NM_020896 NM_145638	NM_001199227 NM_024289 NM_001384163
RefSeq (protein)	NP_001137535 NP_065947 NP_663613	NP_001186156 NP_077251 NP_001371092
Location (UCSC)	Chr 11: 3.09 – 3.17 Mb	Chr 7: 143.69 – 143.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000021762 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037606 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OSBPL5 oxysterol binding protein-like 5".

Further reading

• Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". J. Lipid Res. 40 (12): 2204–11. PMID 10588946.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203–13. PMID 11483621.
• Jaworski CJ, Moreira E, Li A, et al. (2002). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Higashimoto K, Soejima H, Yatsuki H, et al. (2003). "Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse". Genomics. 80 (6): 575–84. doi:10.1006/geno.2002.7006. PMID 12504849.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.