OSBPL1A

Oxysterol-binding protein-related protein 1 is a protein that in humans is encoded by the OSBPL1A gene.[5][6][7]

OSBPL1A
Identifiers
AliasesOSBPL1A, ORP-1, ORP1, OSBPL1B, oxysterol binding protein like 1A
External IDsOMIM: 606730 MGI: 1927551 HomoloGene: 84746 GeneCards: OSBPL1A
Gene location (Human)
Chr.Chromosome 18 (human)[1]
Band18q11.2Start24,162,045 bp[1]
End24,397,880 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

114876

64291

Ensembl

ENSG00000141447

ENSMUSG00000044252

UniProt

Q9BXW6

Q91XL9

RefSeq (mRNA)

NM_001242508
NM_018030
NM_080597
NM_133268

RefSeq (protein)

NP_001229437
NP_060500
NP_542164

Location (UCSC)Chr 18: 24.16 – 24.4 MbChr 18: 12.76 – 12.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000141447 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000044252 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Xu Y, Liu Y, Ridgway ND, McMaster CR (May 2001). "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport". J Biol Chem. 276 (21): 18407–14. doi:10.1074/jbc.M101204200. PMID 11279184.
  6. Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (Feb 2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". J Lipid Res. 40 (12): 2204–11. PMID 10588946.
  7. "Entrez Gene: OSBPL1A oxysterol binding protein-like 1A".

Further reading


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