OSBPL1A

Oxysterol-binding protein-related protein 1 is a protein that in humans is encoded by the OSBPL1A gene.[5][6][7]

OSBPL1A
Identifiers
Aliases	OSBPL1A, ORP-1, ORP1, OSBPL1B, oxysterol binding protein like 1A
External IDs	OMIM: 606730 MGI: 1927551 HomoloGene: 84746 GeneCards: OSBPL1A
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q11.2 Start 24,162,045 bp[1] End 24,397,880 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 12,755,314 bp[2] End 12,941,841 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cholesterol binding • GO:0001948 protein binding • phospholipid binding • lipid binding • sterol transporter activity • sterol binding Cellular component • endosome • late endosome • intracellular • extracellular exosome • cytosol • membrane • intracellular membrane-bounded organelle Biological process • lipid transport • cholesterol metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class II • vesicle-mediated transport • bile acid biosynthetic process • sterol transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114876	64291
Ensembl	ENSG00000141447	ENSMUSG00000044252
UniProt	Q9BXW6	Q91XL9
RefSeq (mRNA)	NM_001242508 NM_018030 NM_080597 NM_133268	NM_001252489 NM_001252490 NM_001252491 NM_001252492 NM_001252493 NM_020573 NM_207530
RefSeq (protein)	NP_001229437 NP_060500 NP_542164	NP_001239418 NP_001239419 NP_001239420 NP_001239421 NP_001239422 NP_997413
Location (UCSC)	Chr 18: 24.16 – 24.4 Mb	Chr 18: 12.76 – 12.94 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000141447 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044252 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xu Y, Liu Y, Ridgway ND, McMaster CR (May 2001). "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport". J Biol Chem. 276 (21): 18407–14. doi:10.1074/jbc.M101204200. PMID 11279184.
6. Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (Feb 2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". J Lipid Res. 40 (12): 2204–11. PMID 10588946.
7. "Entrez Gene: OSBPL1A oxysterol binding protein-like 1A".

Further reading

• Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203–13. PMID 11483621.
• Jaworski CJ, Moreira E, Li A, et al. (2002). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Johansson M, Bocher V, Lehto M, et al. (2004). "The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct". Mol. Biol. Cell. 14 (3): 903–15. doi:10.1091/mbc.E02-08-0459. PMC 151568. PMID 12631712.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Johansson M, Lehto M, Tanhuanpää K, et al. (2006). "The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments". Mol. Biol. Cell. 16 (12): 5480–92. doi:10.1091/mbc.E05-03-0189. PMC 1289395. PMID 16176980.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.