OSBPL11

Oxysterol-binding protein-related protein 11 is a protein that in humans is encoded by the OSBPL11 gene.[5]

OSBPL11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D9X
Identifiers
Aliases	OSBPL11, ORP-11, ORP11, OSBP12, TCCCIA00292, oxysterol binding protein like 11
External IDs	OMIM: 606739 MGI: 2146553 HomoloGene: 23385 GeneCards: OSBPL11
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.2 Start 125,528,858 bp[1] End 125,595,497 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 33,185,071 bp[2] End 33,243,312 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • lipid binding • sterol transporter activity • sterol binding Cellular component • endosome • membrane • late endosome membrane • nucleoplasm • Golgi apparatus • cytosol • intracellular membrane-bounded organelle Biological process • lipid transport • positive regulation of sequestering of triglyceride • fat cell differentiation • sterol transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114885	106326
Ensembl	ENSG00000144909	ENSMUSG00000022807
UniProt	Q9BXB4	Q8CI95
RefSeq (mRNA)	NM_022776	NM_176840
RefSeq (protein)	NP_073613	NP_789810
Location (UCSC)	Chr 3: 125.53 – 125.6 Mb	Chr 16: 33.19 – 33.24 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000144909 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022807 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OSBPL11 oxysterol binding protein-like 11".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, Ikonen E, Olkkonen VM (August 2001). "The OSBP-related protein family in humans". Journal of Lipid Research. 42 (8): 1203–13. PMID 11483621.
• Jaworski CJ, Moreira E, Li A, Lee R, Rodriguez IR (December 2001). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.