ODF1

Outer dense fiber protein 1 is a protein that in humans is encoded by the ODF1 gene.[5][6]

ODF1
Identifiers
Aliases	ODF1, CT133, HSPB10, ODF, ODF2, ODF27, ODFP, ODFPG, ODFPGA, ODFPGB, RT7, SODF, outer dense fiber of sperm tails 1
External IDs	OMIM: 182878 MGI: 97424 HomoloGene: 7456 GeneCards: ODF1
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.3 Start 102,551,589 bp[1] End 102,561,018 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 B3.1|15 15.14 cM Start 38,219,203 bp[2] End 38,226,735 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • protein domain specific binding Cellular component • cell nucleus • outer dense fiber Biological process • multicellular organism development • cell differentiation • spermatogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4956	18285
Ensembl	ENSG00000155087	ENSMUSG00000061923
UniProt	Q14990	Q61999
RefSeq (mRNA)	NM_024410	NM_008757
RefSeq (protein)	NP_077721	NP_032783
Location (UCSC)	Chr 8: 102.55 – 102.56 Mb	Chr 15: 38.22 – 38.23 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000155087 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061923 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gastmann O, Burfeind P, Gunther E, Hameister H, Szpirer C, Hoyer-Fender S (Mar 1994). "Sequence, expression, and chromosomal assignment of a human sperm outer dense fiber gene". Mol Reprod Dev. 36 (4): 407–418. doi:10.1002/mrd.1080360402. PMID 8305202.
6. "Entrez Gene: ODF1 outer dense fiber of sperm tails 1".

Further reading

• Kierszenbaum AL (2002). "Keratins: unraveling the coordinated construction of scaffolds in spermatogenic cells". Mol. Reprod. Dev. 61 (1): 1–2. doi:10.1002/mrd.1124. PMID 11774369.
• Henkel R, Stalf T, Miska W (1992). "Isolation and partial characterization of the outer dense fiber proteins from human spermatozoa". Biol. Chem. Hoppe-Seyler. 373 (8): 685–9. doi:10.1515/bchm3.1992.373.2.685. PMID 1418683.
• Hofferbert S, Burfeind P, Hoyer-Fender S, et al. (1994). "A homozygous deletion of 27 basepairs in the coding region of the human outer dense fiber protein gene does not result in a pathologic phenotype". Hum. Mol. Genet. 2 (12): 2167–2170. doi:10.1093/hmg/2.12.2167. PMID 8111388.
• Burmester S, Hoyer-Fender S (1997). "Transcription and translation of the outer dense fiber gene (Odf1) during spermiogenesis in the rat. A study by in situ analyses and polysome fractionation". Mol. Reprod. Dev. 45 (1): 10–20. doi:10.1002/(SICI)1098-2795(199609)45:1<10::AID-MRD2>3.0.CO;2-V. PMID 8873064.
• Shao X, van der Hoorn FA (1997). "Self-interaction of the major 27-kilodalton outer dense fiber protein is in part mediated by a leucine zipper domain in the rat". Biol. Reprod. 55 (6): 1343–1350. doi:10.1095/biolreprod55.6.1343. PMID 8949892.
• Shao X, Tarnasky HA, Schalles U, et al. (1997). "Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27". J. Biol. Chem. 272 (10): 6105–6113. doi:10.1074/jbc.272.10.6105. PMID 9045620.
• Shao X, Tarnasky HA, Lee JP, et al. (1999). "Spag4, a novel sperm protein, binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme". Dev. Biol. 211 (1): 109–123. doi:10.1006/dbio.1999.9297. PMID 10373309.
• Petersen C, Füzesi L, Hoyer-Fender S (1999). "Outer dense fibre proteins from human sperm tail: molecular cloning and expression analyses of two cDNA transcripts encoding proteins of approximately 70 kDa". Mol. Hum. Reprod. 5 (7): 627–635. doi:10.1093/molehr/5.7.627. PMID 10381817.
• Shao X, Xue J, van der Hoorn FA (2001). "Testicular protein Spag5 has similarity to mitotic spindle protein Deepest and binds outer dense fiber protein Odf1". Mol. Reprod. Dev. 59 (4): 410–416. doi:10.1002/mrd.1047. PMID 11468777.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zarsky HA, Tarnasky HA, Cheng M, van der Hoorn FA (2003). "Novel RING finger protein OIP1 binds to conserved amino acid repeats in sperm tail protein ODF1". Biol. Reprod. 68 (2): 543–552. doi:10.1095/biolreprod.102.009076. PMC 3158802. PMID 12533418.
• Bhullar B, Zhang Y, Junco A, et al. (2003). "Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion". J. Biol. Chem. 278 (18): 16159–16168. doi:10.1074/jbc.M213126200. PMC 3178653. PMID 12594206.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.