OAS3

2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene.[5][6]

OAS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4S3N
Identifiers
Aliases	OAS3, p100, p100OAS, 2'-5'-oligoadenylate synthetase 3
External IDs	OMIM: 603351 MGI: 2180850 HomoloGene: 4510 GeneCards: OAS3
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.13 Start 112,938,444 bp[1] End 112,973,251 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 F|5 60.64 cM Start 120,753,098 bp[2] End 120,777,661 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • nucleotidyltransferase activity • metal ion binding • 2'-5'-oligoadenylate synthetase activity • GO:0001948 protein binding • RNA binding • double-stranded RNA binding • ATP binding Cellular component • cytoplasm • intracellular membrane-bounded organelle • cell membrane • nucleoplasm • cell nucleus • extracellular • cytosol Biological process • regulation of ribonuclease activity • immune system process • interferon-gamma-mediated signaling pathway • response to virus • negative regulation of viral genome replication • defense response to virus • type I interferon signaling pathway • immune response • innate immune system • nucleobase-containing compound metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4940	246727
Ensembl	ENSG00000111331	ENSMUSG00000032661
UniProt	Q9Y6K5	Q8VI93
RefSeq (mRNA)	NM_006187	NM_145226
RefSeq (protein)	NP_006178	NP_660261
Location (UCSC)	Chr 12: 112.94 – 112.97 Mb	Chr 5: 120.75 – 120.78 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of ATP. These oligos activate latent RNase L, leading to degradation of both viral and endogenous RNA. This enzyme family plays a significant role in the inhibition of cellular protein synthesis in response to viral infection.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000111331 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032661 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hovnanian A, Rebouillat D, Mattei MG, Levy ER, Marie I, Monaco AP, Hovanessian AG (Dec 1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms". Genomics. 52 (3): 267–77. doi:10.1006/geno.1998.5443. PMID 9790745.
6. "Entrez Gene: OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa".

Further reading

• Hovanessian AG, Justesen J (2007). "The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation". Biochimie. 89 (6–7): 779–88. doi:10.1016/j.biochi.2007.02.003. PMID 17408844.
• Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818.
• Hovanessian AG, Laurent AG, Chebath J, et al. (1987). "Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies". EMBO J. 6 (5): 1273–80. doi:10.1002/j.1460-2075.1987.tb02364.x. PMC 553929. PMID 2440675.
• Marié I, Blanco J, Rebouillat D, Hovanessian AG (1997). "69-kDa and 100-kDa isoforms of interferon-induced (2'-5')oligoadenylate synthetase exhibit differential catalytic parameters". Eur. J. Biochem. 248 (2): 558–66. doi:10.1111/j.1432-1033.1997.t01-1-00558.x. PMID 9346316.
• Rebouillat D, Hovnanian A, Marié I, Hovanessian AG (1999). "The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains". J. Biol. Chem. 274 (3): 1557–65. doi:10.1074/jbc.274.3.1557. PMID 9880533.
• Rebouillat D, Hovnanian A, David G, et al. (2001). "Characterization of the gene encoding the 100-kDa form of human 2',5' oligoadenylate synthetase". Genomics. 70 (2): 232–40. doi:10.1006/geno.2000.6382. PMID 11112351.
• Ito M, Shichijo S, Tsuda N, et al. (2001). "Molecular basis of T cell-mediated recognition of pancreatic cancer cells". Cancer Res. 61 (5): 2038–46. PMID 11280764.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9Y6K5 (2'-5'-oligoadenylate synthase 3) at the PDBe-KB.