Nucleus incertus

The nucleus incertus is a region of the rodent pontine brainstem just ventral to the 4th ventricle.[1]

Nucleus incertus
Identifiers
NeuroLex IDnlx_144477
Anatomical terms of neuroanatomy

The nucleus incertus has a bilateral structure which sits near the brainstem, and is often also called 'nucleus O'. It consists of mostly ascending GABAergic projection neurons and glutamatergic neurons[2] which innervate a broad range of forebrain regions involved in behavioural activation and the response to stress.[3]

This tegmental nucleus is part of the theta network. The nucleus incertus is a relay from the reticularis pontis oralis nucleus to the septo-hippocampal system.[4] The stimulation of the nucleus incertus activates the hippocampal theta rhythm and either its lesion or inhibition suppress the theta oscillation induced by brainstem stimulation.[5] The nucleus incertus itself presents theta oscillations coupled to the hippocampal theta rhythm.[6]

References
  1. Goto, M; Swanson, LW; Canteras, NS (Sep 10, 2001). "Connections of the nucleus incertus". The Journal of Comparative Neurology. 438 (1): 86–122. doi:10.1002/cne.1303. PMID 11503154.
  2. Cervera-Ferri, A; Rahmani, Y; Martínez-Bellver, S; Teruel-Martí, V; Martínez-Ricós, J (May 31, 2012). "Glutamatergic projection from the nucleus incertus to the septohippocampal system". Neuroscience Letters. 517 (2): 71–6. doi:10.1016/j.neulet.2012.04.014. PMID 22521581.
  3. Ryan, Phil; Ma S; Olucha-Bordonau FE; Gundlach AL (May 2011). "Nucleus incertus--an emerging modulatory role in arousal, stress and memory". Neuroscience & Biobehavioral Reviews. 35 (6): 1326–41. doi:10.1016/j.neubiorev.2011.02.004. PMID 21329721.
  4. Teruel-Martí, V; Cervera-Ferri, A; Nuñez, A; Valverde-Navarro, AA; Olucha-Bordonau, FE; Ruiz-Torner, A (Jul 7, 2008). "Anatomical evidence for a ponto-septal pathway via the nucleus incertus in the rat". Brain Research. 1218: 87–96. doi:10.1016/j.brainres.2008.04.022. PMID 18514169.
  5. Nuñez, A; Cervera-Ferri, A; Olucha-Bordonau, F; Ruiz-Torner, A; Teruel, V (May 2006). "Nucleus incertus contribution to hippocampal theta rhythm generation". The European Journal of Neuroscience. 23 (10): 2731–8. doi:10.1111/j.1460-9568.2006.04797.x. PMID 16817876.
  6. Cervera-Ferri, A; Guerrero-Martínez, J; Bataller-Mompeán, M; Taberner-Cortes, A; Martínez-Ricós, J; Ruiz-Torner, A; Teruel-Martí, V (Jun 2011). "Theta synchronization between the hippocampus and the nucleus incertus in urethane-anesthetized rats". Experimental Brain Research. 211 (2): 177–92. doi:10.1007/s00221-011-2666-3. PMID 21479657.


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