Nucleolar phosphoprotein p130

Nucleolar phosphoprotein p130 is a protein that in humans is encoded by the NOLC1 gene.[3][4][5]

NOLC1
Identifiers
Aliases	NOLC1, NOPP130, NOPP140, NS5ATP13, P130, Nucleolar phosphoprotein p130, nucleolar and coiled-body phosphoprotein 1, Srp40
External IDs	OMIM: 602394 HomoloGene: 68818 GeneCards: NOLC1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.32 Start 102,152,176 bp[1] End 102,163,871 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GTP binding • GO:0001948 protein binding • ATP binding • RNA binding • RNA polymerase I core binding • protein heterodimerization activity • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • nuclear localization sequence binding • protein domain specific binding • box C/D snoRNA binding • box H/ACA snoRNA binding • box C/D snoRNP complex binding • box H/ACA snoRNP complex binding Cellular component • cytoplasm • Cajal body • cell nucleus • nucleoplasm • nucleolus • fibrillar center • box C/D snoRNP complex • box H/ACA snoRNP complex Biological process • rRNA processing • cell cycle • nucleolus organization • regulation of translation • neural crest formation • neural crest cell development • GO:0007067 mitotic cell cycle • response to osmotic stress • positive regulation of cell proliferation • box H/ACA snoRNA metabolic process • regulation of protein import into nucleus • positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9221	n/a
Ensembl	ENSG00000166197	n/a
UniProt	Q14978	n/a
RefSeq (mRNA)	NM_001284388 NM_001284389 NM_004741	n/a
RefSeq (protein)	NP_001271317 NP_001271318 NP_004732	n/a
Location (UCSC)	Chr 10: 102.15 – 102.16 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Interactions

Nucleolar phosphoprotein p130 has been shown to interact with coilin[6] and CEBPB.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000166197 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Pai CY, Chen HK, Sheu HL, Yeh NH (Oct 1995). "Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis". J Cell Sci. 108. ( Pt 5): 1911–20. PMID 7657714.
4. Chen HK, Pai CY, Huang JY, Yeh NH (Jan 2000). "Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization". Mol Cell Biol. 19 (12): 8536–46. doi:10.1128/MCB.19.12.8536. PMC 84972. PMID 10567578.
5. "Entrez Gene: NOLC1 nucleolar and coiled-body phosphoprotein 1".
6. Isaac, C; Yang Y; Meier U T (Jul 1998). "Nopp140 functions as a molecular link between the nucleolus and the coiled bodies". J. Cell Biol. 142 (2): 319–29. doi:10.1083/jcb.142.2.319. ISSN 0021-9525. PMC 2133063. PMID 9679133.
7. Miau, L H; Chang C J; Shen B J; Tsai W H; Lee S C (Apr 1998). "Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation". J. Biol. Chem. 273 (17): 10784–91. doi:10.1074/jbc.273.17.10784. ISSN 0021-9258. PMID 9553145.

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Pai CY, Yeh NH (1996). "Cell proliferation-dependent expression of two isoforms of the nucleolar phosphoprotein p130". Biochem. Biophys. Res. Commun. 221 (3): 581–7. doi:10.1006/bbrc.1996.0639. PMID 8630004.
• Miau LH, Chang CJ, Tsai WH, Lee SC (1997). "Identification and characterization of a nucleolar phosphoprotein, Nopp140, as a transcription factor". Mol. Cell. Biol. 17 (1): 230–9. doi:10.1128/MCB.17.1.230. PMC 231747. PMID 8972203.
• Li D, Meier UT, Dobrowolska G, Krebs EG (1997). "Specific interaction between casein kinase 2 and the nucleolar protein Nopp140". J. Biol. Chem. 272 (6): 3773–9. doi:10.1074/jbc.272.6.3773. PMID 9013635.
• Chen HK, Yeh NH (1997). "The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic property to form large complexes triggered by F- and Mg2+". Biochem. Biophys. Res. Commun. 230 (2): 370–5. doi:10.1006/bbrc.1996.5966. PMID 9016786.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Miau LH, Chang CJ, Shen BJ, et al. (1998). "Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation". J. Biol. Chem. 273 (17): 10784–91. doi:10.1074/jbc.273.17.10784. PMID 9553145.
• Isaac C, Yang Y, Meier UT (1998). "Nopp140 functions as a molecular link between the nucleolus and the coiled bodies". J. Cell Biol. 142 (2): 319–29. doi:10.1083/jcb.142.2.319. PMC 2133063. PMID 9679133.
• Blanchette P, Gilchrist CA, Baker RT, Gray DA (2001). "Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130". Oncogene. 20 (39): 5533–7. doi:10.1038/sj.onc.1204823. PMID 11571651.
• Chiu CM, Tsay YG, Chang CJ, Lee SC (2002). "Nopp140 is a mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid glycoprotein gene". J. Biol. Chem. 277 (42): 39102–11. doi:10.1074/jbc.M205915200. PMID 12167624.
• Wang C, Query CC, Meier UT (2003). "Immunopurified small nucleolar ribonucleoprotein particles pseudouridylate rRNA independently of their association with phosphorylated Nopp140". Mol. Cell. Biol. 22 (24): 8457–66. doi:10.1128/MCB.22.24.8457-8466.2002. PMC 139890. PMID 12446766.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.