Ethinylestradiol/norethisterone acetate

Ethinylestradiol/norethisterone acetate (EE/NETA), or ethinylestradiol/norethindrone acetate, is a combination of ethinylestradiol (EE) and norethisterone acetate (NETA) which is used as birth control.[1] EE is an estrogen, while norethisterone acetate (NETA) is a progestin.[1] It is taken by mouth.[1]

Not to be confused with Ethinylestradiol/norethisterone.

Ethinylestradiol /
norethisterone acetate

Combination of
Ethinylestradiol	Estrogen
Norethisterone acetate	Progestogen
Clinical data
Trade names	Estrostep, Loestrin, Microgestin, others[1]
Other names	EE/NETA
AHFS/Drugs.com	Professional Drug Facts
License data	US DailyMed: Norethindrone_acetate_and_ethinyl_estradiol
Pregnancy category	US: X (Contraindicated)
Routes of administration	By mouth (pill)
ATC code	G03AA05 (WHO)
Legal status
Legal status	US: ℞-only
Identifiers
CAS Number	57-63-6 68-22-4
PubChem CID	63020
DrugBank	DB00977 DB00717
UNII	423D2T571U 9S44LIC7OJ
KEGG	D00554 D00182
ChEBI	CHEBI:4903 CHEBI:7627
ChEMBL	ChEMBL691 ChEMBL1162
Chemical and physical data
3D model (JSmol)	Interactive image
SMILES CC(=O)OC1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34)C)C#C.CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O
InChI InChI=1S/C22H28O3.C20H24O2/c1-4-22(25-14(2)23)12-10-20-19-7-5-15-13-16(24)6-8-17(15)18(19)9-11-21(20,22)3;1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,13,17-20H,5-12H2,2-3H3;1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t17-,18+,19+,20-,21-,22-;16-,17-,18+,19+,20+/m01/s1 Key:GEONECATAKDDLT-JDSZYESASA-N

In 2017, it was the 53rd most commonly prescribed medication in the United States, with more than 14 million prescriptions.[2][3]

Society and culture

Brand names

Brand names of EE/NETA include Anovlar, Blisovi, Cumorit, Estrostep, FemHRT, Fyavolv, Gildess, Junel, Larin, Leribane, Loestrin, Mibelas, Microgestin, Minastrin, Norlestrin, Primodos, Taytulla, and Tri-Legest, among others.[4]

In addition, the combination is sold in the United States under the brand name FemHRT for use in menopausal hormone therapy.[5][6]

See also

• Estradiol/norethisterone acetate
• Oral contraceptive formulations
• List of combined sex-hormonal preparations

References

1. "Estrogen-Progestin Combinations Monograph for Professionals". Drugs.com. AHFS. Retrieved 28 December 2018.
2. "The Top 300 of 2020". ClinCalc. Retrieved 10 April 2020.
3. "Ethinyl Estradiol; Norethindrone - Drug Usage Statistics". ClinCalc. Retrieved 10 April 2020.
4. "Ethinyl Estradiol and Norethindrone (Professional Patient Advice)". Drugs.com. 13 July 2019. Retrieved 10 April 2020.
5. "Drug Approval Package: Femhrt (Norethindrone Acetate & Ethinyl Estradiol) NDA #21065". U.S. Food and Drug Administration (FDA). Retrieved 28 December 2018.
6. "FemHRT- norethindrone acetate/ethinyl estradiol tablet". DailyMed. 14 November 2017. Retrieved 31 December 2019.

External links

• "Ethinyl estradiol mixture with norethindrone acetate". Drug Information Portal. U.S. National Library of Medicine.