Nocardia farcinica

Nocardia farcinica is a species of bacteria and a member of the genus Nocardia. This species is very similar in phenotype to Nocardia asteroides, to the degree that some isolates of N. asteroides were later found to be Nocardia farcinica.[2]

Nocardia farcinica
Scientific classification
Kingdom:
Bacteria
Phylum:
Actinobacteria
Order:
Actinomycetales
Suborder:
Corynebacterineae
Family:
Nocardiaceae
Genus:
Nocardia
Species:
N. farcinica
Binomial name
Nocardia farcinica
Trevisan 1889[1]

Pathogenicity

N. farcinica may be a causative agent of nocardiosis[3] or of secondary infections in immunocompromised patients.[4] Strains of this species have been isolated from human brain abscesses.[5]

Genome

N. farcinica contains a 6 million base pair genome with an average GC content of 70.8%. A sequenced strain, IFM 10152, is also known to contain two plasmids, pNF1 pNF2. The chromosome encodes 5,674 potential protein-coding open reading frames. This genome may have undergone numerous gene duplication events as a result of adapting to new environments.[6]

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References
  1. Parte, A.C. "Nocardia". LPSN.
  2. Wallace RJ, Jr; Tsukamura, M; Brown, BA; Brown, J; Steingrube, VA; Zhang, YS; Nash, DR (December 1990). "Cefotaxime-resistant Nocardia asteroides strains are isolates of the controversial species Nocardia farcinica". Journal of Clinical Microbiology. 28 (12): 2726–32. PMC 268263. PMID 2280003.
  3. Holm, P (July 1975). "Seven cases of human nocardiosis caused by Nocardia farcinica". Sabouraudia. 13 (2): 161–9. doi:10.1080/00362177585190301. PMID 1162538.
  4. Torres, O. H.; Domingo, P.; Pericas, R.; Boiron, P.; Montiel, J. A.; Vázquez, G. (3 April 2000). "Infection Caused by Nocardia farcinica : Case Report and Review". European Journal of Clinical Microbiology & Infectious Diseases. 19 (3): 205–212. doi:10.1007/s100960050460.
  5. Malincarne, Lisa; Marroni, Massimo; Farina, Claudio; Camanni, Guido; Valente, Marina; Belfiori, Barbara; Fiorucci, Stefano; Floridi, Piero; Cardaccia, Angela; Stagni, Giuliano (1 May 2002). "Primary brain abscess with Nocardia farcinica in an immunocompetent patient". Clinical Neurology and Neurosurgery. 104 (2): 132–135. doi:10.1016/S0303-8467(01)00201-3. PMID 11932043.
  6. Ishikawa, J; Yamashita, A; Mikami, Y; Hoshino, Y; Kurita, H; Hotta, K; Shiba, T; Hattori, M (Oct 12, 2004). "The complete genomic sequence of Nocardia farcinica IFM 10152". Proceedings of the National Academy of Sciences of the United States of America. 101 (41): 14925–30. doi:10.1073/pnas.0406410101. PMC 522048. PMID 15466710.

Further reading
  • Malla, Sailesh; Pandey, Ramesh Prasad; Kim, Byung-Gee; Sohng, Jae Kyung (22 April 2013). "Regiospecific modifications of naringenin for astragalin production in Escherichia coli". Biotechnology and Bioengineering. 110 (9): 2525–2535. doi:10.1002/bit.24919. PMID 23568509.
  • Toyomitsu, Sawai (April 8, 2014). "A case of community-acquired pneumonia due to influenza A virus and Nocardia farcinica co-infection". Journal of Infection and Chemotherapy. 20 (8): 506–508. doi:10.1016/j.jiac.2014.04.008. PMID 24855916.


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