Nizofenone

Nizofenone (Ekonal, Midafenone) is a neuroprotective drug which protects neurons from death following cerebral anoxia (interruption of oxygen supply to the brain). It might thus be useful in the treatment of acute neurological conditions such as stroke.[1][2][3][4]

Nizofenone
Clinical data
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Chemical and physical data
FormulaC21H21ClN4O3
Molar mass412.87 g·mol−1
3D model (JSmol)
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References

  1. Ohta T, Kikuchi H, Hashi K, Kudo Y (March 1986). "Nizofenone administration in the acute stage following subarachnoid hemorrhage. Results of a multi-center controlled double-blind clinical study". Journal of Neurosurgery. 64 (3): 420–6. doi:10.3171/jns.1986.64.3.0420. PMID 3512795.
  2. Yasuda H, Izumi N, Nakanishi M, Maruyama Y (1988). "Brain protection against oxygen deficiency by nizofenone". Advances in Experimental Medicine and Biology. 222: 403–10. doi:10.1007/978-1-4615-9510-6_48. ISBN 978-1-4615-9512-0. PMID 3364265.
  3. Yasuda H, Nakajima A (1993). "Brain protection against ischemic injury by nizofenone". Cerebrovascular and Brain Metabolism Reviews. 5 (4): 264–76. PMID 8110594.
  4. Matsumoto Y, Aihara K, Kamata T, Goto N (September 1994). "Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation". European Journal of Pharmacology. 262 (1–2): 157–61. doi:10.1016/0014-2999(94)90039-6. PMID 7813567.


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