Niles Pierce

Niles A. Pierce is an American mathematician, bioengineer, and professor at the California Institute of Technology. He is a leading researcher in the fields of molecular programming and dynamic nucleic acid nanotechnology. His research is focused on kinetically controlled DNA and RNA self-assembly. Pierce is working on applications in bioimaging.

Pierce graduated from Princeton University in 1993 with a BSE in Mechanical & Aerospace Engineering. He attended Oxford University as a Rhodes Scholar, an achievement repeated nine years later by his sister Lillian Pierce.[1] He completed a DPhil in Applied Mathematics in 1997. He joined the faculty of the California Institute of Technology in 2000.

Works
  • Next-generation in situ hybridization chain reaction: higher gain, lower cost, greater durability H.M.T. Choi, V.A. Beck, and N.A. Pierce ACS Nano 8(5):4284-4294, 2014.
  • Conditional Dicer substrate formation via shape and sequence transduction with small conditional RNAs L.M. Hochrein, M. Schwarzkopf, M. Shahgholi, P. Yin, and N.A. Pierce J Am Chem Soc 135(46):17322-17330, 2013.
  • Nucleic acid sequence design via efficient ensemble defect optimization J.N. Zadeh, B.R. Wolfe, and N.A. Pierce J Comput Chem 32:439-452, 2011.
  • NUPACK: Analysis and design of nucleic acid systems J.N. Zadeh, C.D. Steenberg, J.S. Bois, B.R. Wolfe, M.B. Pierce, A.R. Khan, R.M. Dirks, and N.A. Pierce J Comput Chem 32:170-173, 2011.
  • Programmable in situ amplification for multiplexed imaging of mRNA expression H.M.T. Choi, J.Y. Chang, L.A. Trinh, J.E. Padilla, S.E. Fraser, and N.A. Pierce Nature Biotechnol 28:1208-1212, 2010.
  • Programming biomolecular self-assembly pathways P. Yin, H.M.T. Choi, C.R. Calvert, and N.A. Pierce Nature 451:318-322, 2008.
  • Thermodynamic analysis of interacting nucleic acid strands R.M. Dirks, J.S. Bois, J.M. Schaeffer, E. Winfree, and N.A. Pierce SIAM Rev 49(1):65-88, 2007.
  • Triggered amplification by hybridization chain reaction R.M. Dirks and N.A. Pierce Proc Natl Acad Sci USA 101(43):15275-15278, 2004.
  • A synthetic DNA walker for molecular transport J.-S. Shin and N.A. Pierce J Am Chem Soc 126:10834-10835, 2004.

Resources
  • NUPACK is a growing software suite for the analysis and design of nucleic acid structures, devices, and systems.
  • Molecular Technologies develops and supports programmable molecular technologies for reading out and regulating the state of endogenous biological circuitry.

Startup Company
  • Molecular Instruments, Inc. designs and synthesizes molecular kits for multiplexed quantitative bioimaging in academic research, drug development, and clinical diagnostics.
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gollark: > Two things are infinite: the universe and human stupidity; and I'm not sure about the universe. -Albert einsteinTwo things are infinite: the universe and fake Albert Einstein quotes; and I'm not sure about the universe. -Albert einstein

References
  1. Stevens, Ruth (June 3, 2002), "Selection as valedictorian a family affair for the Pierces", Princeton Weekly Bulletin, 92 (27)
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