Neurotrimin

Neurotrimin is a protein that in humans is encoded by the NTM gene.[5][6]

NTM
Identifiers
Aliases	NTM, HNT, IGLON2, NTRI, neurotrimin, CEPU-1
External IDs	OMIM: 607938 MGI: 2446259 HomoloGene: 41139 GeneCards: NTM
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q25 Start 131,370,478 bp[1] End 132,336,822 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A4 Start 28,994,750 bp[2] End 29,963,141 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • anchored component of membrane • membrane • extracellular region • cell membrane Biological process • neuron recognition • cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50863	235106
Ensembl	ENSG00000182667	ENSMUSG00000059974
UniProt	Q9P121	Q99PJ0
RefSeq (mRNA)	NM_001048209 NM_001144058 NM_001144059 NM_016522 NM_001352001 NM_001352002 NM_001352003 NM_001352004 NM_001352005 NM_001352006 NM_001352007 NM_001352008 NM_001352009	NM_172290 NM_001357593 NM_001357597 NM_001357598 NM_001357601 NM_001357602 NM_001357603
RefSeq (protein)	NP_001041674 NP_001137530 NP_001137531 NP_057606 NP_001338930 NP_001338931 NP_001338932 NP_001338933 NP_001338934 NP_001338935 NP_001338936 NP_001338937 NP_001338938	NP_758494 NP_001344522 NP_001344526 NP_001344527 NP_001344530 NP_001344531 NP_001344532
Location (UCSC)	Chr 11: 131.37 – 132.34 Mb	Chr 9: 28.99 – 29.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML) on chromosome 11. Multiple alternatively spliced variants have been found but only two variants have had their full-length sequences determined.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000182667 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059974 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Struyk AF, Canoll PD, Wolfgang MJ, Rosen CL, D'Eustachio P, Salzer JL (Apr 1995). "Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules". J Neurosci. 15 (3 Pt 2): 2141–56. doi:10.1523/JNEUROSCI.15-03-02141.1995. PMID 7891157.
6. "Entrez Gene: HNT neurotrimin".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sellar GC, Watt KP, Rabiasz GJ, et al. (2003). "OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer". Nat. Genet. 34 (3): 337–43. doi:10.1038/ng1183. PMID 12819783.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Liu J, Li G, Peng X, et al. (2004). "The cloning and preliminarily functional analysis of the human neurotrimin gene". Science in China Series C: Life Sciences. 47 (2): 158–64. doi:10.1360/03yc0072. PMID 15379248.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.