Neurogenin-1

Neurogenin-1 is a protein that in humans is encoded by the NEUROG1 gene.[5][6]

NEUROG1
Identifiers
Aliases	NEUROG1, AKA, Math4C, NEUROD3, bHLHa6, ngn1, neurogenin 1
External IDs	OMIM: 601726 MGI: 107754 HomoloGene: 4490 GeneCards: NEUROG1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 135,534,282 bp[1] End 135,535,964 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 B1|13 30.06 cM Start 56,250,478 bp[2] End 56,252,163 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • chromatin binding • GO:0001948 protein binding • protein homodimerization activity • E-box binding • sequence-specific double-stranded DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • perikaryon • neuronal cell body • cell nucleus Biological process • regulation of neuron differentiation • neurogenesis • cell differentiation • cell fate commitment • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of exit from mitosis • transcription, DNA-templated • nervous system development • multicellular organism development • positive regulation of neuron differentiation • neuron differentiation • positive regulation of transcription from RNA polymerase II promoter • thorax and anterior abdomen determination • trigeminal nerve development • vestibulocochlear nerve formation • peristalsis • auditory behavior • genitalia morphogenesis • inner ear morphogenesis • regulation of muscle organ development • genitalia development • inner ear development • neuromuscular process controlling balance • mastication • cochlea development • cochlea morphogenesis • craniofacial suture morphogenesis • learned vocalization behavior • negative regulation of relaxation of muscle • negative regulation of saliva secretion • hard palate morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4762	18014
Ensembl	ENSG00000181965	ENSMUSG00000048904
UniProt	Q92886	P70660
RefSeq (mRNA)	NM_006161	NM_010896
RefSeq (protein)	NP_006152	NP_035026
Location (UCSC)	Chr 5: 135.53 – 135.54 Mb	Chr 13: 56.25 – 56.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

NEUROG1 has been shown to interact with CREB-binding protein[7] and decapentaplegic homolog 1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000181965 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048904 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Mar 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics. 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405.
6. "Entrez Gene: NEUROG1 neurogenin 1".
7. Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME (Feb 2001). "Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms". Cell. 104 (3): 365–76. doi:10.1016/S0092-8674(01)00224-0. PMID 11239394.

Further reading

• McCormick MB, Tamimi RM, Snider L, Asakura A, Bergstrom D, Tapscott SJ (Oct 1996). "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family". Molecular and Cellular Biology. 16 (10): 5792–800. doi:10.1128/mcb.16.10.5792. PMC 231580. PMID 8816493.
• Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME (Feb 2001). "Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms". Cell. 104 (3): 365–76. doi:10.1016/S0092-8674(01)00224-0. PMID 11239394.
• Franklin A, Kao A, Tapscott S, Unis A (Nov 2001). "NeuroD homologue expression during cortical development in the human brain". Journal of Child Neurology. 16 (11): 849–53. doi:10.1177/08830738010160111201. PMID 11732772.
• Kim S, Ghil SH, Kim SS, Myeong HH, Lee YD, Suh-Kim H (Dec 2002). "Overexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells". Experimental & Molecular Medicine. 34 (6): 469–75. doi:10.1038/emm.2002.65. PMID 12526089.
• Fanous AH, Chen X, Wang X, Amdur RL, O'Neill FA, Walsh D, Kendler KS (Mar 2007). "Association between the 5q31.1 gene neurogenin1 and schizophrenia". American Journal of Medical Genetics Part B. 144B (2): 207–14. doi:10.1002/ajmg.b.30423. PMID 17044100.
• Liscovitch N, Chechik G (2013). "Specialization of gene expression during mouse brain development". PLOS Computational Biology. 9 (9): e1003185. Bibcode:2013PLSCB...9E3185L. doi:10.1371/journal.pcbi.1003185. PMC 3777910. PMID 24068900.