Net acid excretion

In renal physiology, net acid excretion (NAE) is the net amount of acid excreted in the urine per unit time. Its value depends on urine flow rate, urine acid concentration, and the concentration of bicarbonate in the urine (the loss of bicarbonate, a buffering agent, is physiologically equivalent to a gain in acid). NAE is commonly expressed in units of milliliters per minute (ml/min) and is given by the following equation:

where

VariableMeaning
NAEnet acid excretion
Vvolume of urine produced per unit time
UNH4urine concentration of ammonium
UTAurine concentration of titratable acid (e.g., phosphoric acid, sulfuric acid)
UHCO3urine concentration of bicarbonate

Pathology

Increased net acid excretion is a compensation for respiratory acidosis, while decreased net acid excretion is a compensation for respiratory alkalosis.[1]

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References

  1. "Archived copy". Archived from the original on 2007-10-24. Retrieved 2007-10-24.CS1 maint: archived copy as title (link)
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