Neoscytalidium dimidiatum

Neoscytalidium dimidiatum was first described in 1933 as Hendersonula toruloidea from diseased orchard trees in Egypt.[3] Decades later, it was determined to be a causative agent of human dermatomycosis-like infections and foot infections predominantly in the tropical areas; however the fungus is considered to be widespread.[3] A newer name, Scytalidium dimidiatum, was applied to synanamorph of Nattrassia mangiferae,[4] otherwise known as Neofusicoccum mangiferae. Substantial confusion has arisen in the literature on this fungus resulting from the use of multiple different names including: Torula dimidiata, Scytalidium dimidiatum, Fusicoccum dimidiatum,[1] and Hendersonula toruloidea.[5]

Neoscytalidium dimidiatum
Scientific classification
Kingdom:
Fungi
Division:
Ascomycota
Class:
Dothideomycetes
Order:
Botryosphaeriales
Family:
Botryosphaeriaceae
Genus:
Neoscytalidium
Species:
N. dimidiatum
Binomial name
Neoscytalidium dimidiatum
(Penz.) Crous & Slippers (2006)[1][2]
Synonyms
  • Torula dimidiata Penz. (1882)[1]
  • Hendersonula toruloidea Nattrass (1933)[1]
  • Scytalidium dimidiatum (Penz.) B. Sutton & Dyko (1989)[1]
  • Fusicoccum dimidiatum (Penz.) D.F. Farr (2005)[1]

History and taxonomy

In 1933, British mycologist Dr. Rolland Marshall Nattrass described an arthroconidial asexual fungus that he named H. toruloidea that was responsible for causing die-back disease of plum, apricot and apple trees in Egypt.[3] At the time, he recognized that single spore cultures of the fungus yielded two "forms" in culture - a mycelial form resembling members of the genus Torula that produced fragmenting chains of arthroconidia, and a pycnicial form characterized by the production of greenish, ellipsoidal spores that oozed from tiny sacs.[6] The name H. toruloidea applied to the latter pycnidial form.[6] Others likened the Torula form to Torula dimidiata described by Otto Penzig in 1882. Despite that the fungus was known by this name for over 50 years by one or the other of these names, increased scrutiny of the species and its close relatives using molecular genetic methods spawned significant controversy in its taxonomy and naming.[3][5]

In 1989 Sutton and Dyko created the genus Nattrassia to accommodate H. toruloidea and applied the name Scytalidium dimidiatum to the mycelial synanamorph.[3] They also included in the new genus Nattrassia a fungus described by father-son mycologists Paul and Hans Sydow as Dothiorella mangiferae, which became Nattrassia mangiferae, thought to be very closely related to and perhaps indistinguishable from Nattrass's original pycnidial form. Farr and coworkers recognized that both states were asexual forms affiliated with the genus Fusicoccum, an anamorph of the plant pathogenic ascomycete genus, Botryosphaeria.[3] They proposed the transfer of Scytalidium dimidiatum to the genus Fusicoccum as F. dimidiatum.[3] A reappraisal of the family Botryosphaeriaceae by Crous and coworkers in 2006 concluded that the genus Fusicoccum was polyphyletic, and they created a new genus, Neoscytalidium to accommodate Nattrass's fungus. Separately they erected the genus Neofusicoccum to accommodate Nattrassia mangiferae.[3][5] Crous and colleagues concluded it inappropriate to collapse the entirety of Scytalidium with Fusicoccum because they demonstrated N. dimidiatum to be phylogenetically distinct from Neofusicoccum mangiferae; thus, they interpreted N. dimidiatum to be the correct name for Nattrass's fungus.[3]

Growth and morphology
UAMH 10614 Neoscytalidium dimidiatum on CER agar incubated at 35 C for 29 days.

This filamentous fungus[3] produces sinuous and irregular hyphae and is characterized by rapidly growing colonies that are deeply tufted with dense, darkly coloured, ropy aerial mycelium.[5][7][8] Cultures are rapidly growing, initially light in colour and becoming dark brown and then black with age.[7] Both arthroconidia and pycnidia may be produced in the same culture.[5] Cultures of the fungus derived from human skin tend to be black in colouration.[5]

Habitat and ecology

Neoscytalidium dimidiatum is mainly found in tropical to subtropical environments,[9] such as in South America, Southeast Asia, India and Africa.[3][5] In addition to these regions, this fungus is endemic to parts of west and central Africa, the Caribbean and Asian,[5] but more cases are being seen in temperate countries, possibly as a consequence of immigration from tropical regions.[10] The fungus occurs in nature in soil and on decaying wood.[9]

Human infection

Neoscytalidium dimidiatum has been describe as an agent to cause infections referred to as dermatomycosis, onychomycosis,[8] ringworm or tinea,[10] affecting human nails, toe webs and feet, and skin,[3][9][11] forming hyphomycete,[11] and also sometimes infecting the palms of hands but this is a rare occurrence.[3] To cause these infections in humans, infections occurs through contact with contaminated soil or plant materials, or nail or skin tissue from an infected person,[5] causing superficial skin infections similar to dermatophytosis called Scytalidiosis.[3] Although established to cause dermatomycosis and onychomycosis, invasive infection by N. dimidiatum is rare, resulting in limited case reports and limited information available for clinical progression and treatment.[8] as well as there is no currently know oral or topical treatment for infection with this fungus.[10] These result in the invasion of tissue and organs causing systemic diseases.[12] Infection can occur in both immunocompetent and immunosuppressed patients,[12] but deep infections occur mainly in immunosuppressed/ immunocompromised individuals with a 50% case mortality.[3] Melanin is characteristically produced by the fungus in vivo in diseased human tissue where its presence has been interpreted as an important pathogenic factor.[13] Although limited in case reports, there have been some reported cases of N. dimidiatum causing dermatomycosis or onychomycosis in places such as Jamaica, Brazil, Algeria, Canada, the United States and the United Kingdom.[14] In addition, there have been some papers reporting infections besides dermatomycosis and onychomycosis, such as discovery of this fungus confirmed by DNA analysis to cause a fatal case of lung disease.[8] Similarly, a case of lung infection has been reported in a dolphin.[15] A case of rhinosinusitis, a disease where it is believed that fungi play a role in the disease process, was reported to have been caused by N. dimidiatum.[16]

Plant disease

Neoscytalidium dimidiatum has been mainly described as an opportunistic[17] plant pathogen,[13] causing pit canker and spot on the stem of plants or fruits, as well as internal black rot of fruits,[17] but a case of internal brown rot of pitahaya was reported from China.[17] Similarly in Malaysia was a report of the fungus causing stem canker of red-fleshed dragon fruit,[18] and a similar report of stem canker on grapevine in California.[19]

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References
  1. "MycoBank Database". www.mycobank.org. Retrieved 9 October 2016.
  2. "Index Fungorum - Names Record". www.indexfungorum.org.
  3. Machouart, M.; Menir, P.; Helenon, R.; Quist, D.; Desbois, N. (March 2013). "Scytalidium and scytalidiosis: What's new in 2012?". Journal de Mycologie Médicale / Journal of Medical Mycology. 23 (1): 40–46. doi:10.1016/j.mycmed.2013.01.002. PMID 23416171.
  4. Howard, Dexter H. (2003). Pathogenic fungi in humans and animals (2nd ed.). New York [u.a.]: Dekker. ISBN 978-0-8247-0683-8.
  5. Tan, Darrell H. S.; Sigler, Lynne; Gibas, Connie F. C.; Fong, Ignatius W. (January 2008). "Disseminated fungal infection in a renal transplant recipient involving Macrophomina phaseolina and Scytalidium dimidiatum: case report and review of taxonomic changes among medically important members of the Botryosphaeriaceae". Medical Mycology. 46 (3): 285–292. doi:10.1080/13693780701759658. PMID 18404556.
  6. Nattrass, Roland Marshall (1933). "A new species of Hendersonula (H. Toruloidea) on deciduous trees in Egypt". Transactions of the British Mycological Society. 18 (3): 189–198. doi:10.1016/S0007-1536(33)80030-1.
  7. Madrid, H; Ruíz-Cendoya, M; Cano, J; Stchigel, A; Orofino, R; Guarro, J (October 2009). "Genotyping and in vitro antifungal susceptibility of Neoscytalidium dimidiatum isolates from different origins". International Journal of Antimicrobial Agents. 34 (4): 351–4. doi:10.1016/j.ijantimicag.2009.05.006. PMID 19570656.
  8. Dionne, Brandon; Neff, Luke; Lee, Samuel A.; Sutton, Deanna A.; Wiederhold, Nathan P.; Lindner, Jonathan; Fan, Hongxin; Jakeman, Bernadette; Warnock, D. W. (July 2015). "Pulmonary Fungal Infection Caused by Neoscytalidium dimidiatum". Journal of Clinical Microbiology. 53 (7): 2381–2384. doi:10.1128/JCM.00206-15. PMC 4473236. PMID 25948605.
  9. Kwon-Chung, K.J; Bennett, J.E. (1992). Medical mycology. Philadelphia: Lea & Febiger. ISBN 978-0812114638.
  10. Alshawa, Kinda; Beretti, Jean-Luc; Lacroix, Claire; Feuilhade, Martine; Dauphin, Brunhilde; Quesne, Gilles; Hassouni, Noura; Nassif, Xavier; Bougnoux, Marie-Elisabeth (1 July 2012). "Successful identification of clinical dermatophyte and Neoscytalidium species by matrix-assisted laser desorption ionization-time of flight mass spectrometry". Journal of Clinical Microbiology. 50 (7): 2277–2281. doi:10.1128/JCM.06634-11. ISSN 1098-660X. PMC 3405581. PMID 22535981.
  11. Rippon, John Willard (1982). Medical Mycology The Pathogenic Fungi and The Pathogenic Actinomycetes (Second ed.). Philadelphia, PA: W. B. Saunders Company. p. 241.
  12. da Silva, Roberta Teixeira; Guimarães, Dávson A.; Camargo, Zoilo P.; Rodrigues, Anderson M.; Maceira, Juan P.; Bernardes-Engemann, Andréa R.; Orofino-Costa, Rosane (1 November 2016). "Cutaneous murine model of infection caused by Neoscytalidium dimidiatum: a preliminary study of an emerging human pathogen". Medical Mycology. 54 (8): 890–898. doi:10.1093/mmy/myw034. ISSN 1460-2709. PMID 27250925.
  13. Ruíz-Cendoya, M; Madrid, H; Pastor, FJ; Mayayo, E; Mariné, M; Guarro, J (August 2010). "Development of murine models of disseminated infection by Neoscytalidium dimidiatum". Medical Mycology. 48 (5): 681–6. doi:10.3109/13693780903452917. PMID 20055737.
  14. "UAMH Centre for Global Microfungal Biodiversity". www.uamh.ca.
  15. Morick, Danny; Alvarez, Mariano Domingo; Elad, Daniel (1 August 2011). "Pulmonary fungal infection caused by Neoscytalidium dimidiatum in a Risso's dolphin (Grampus griseus)--update". Medical Mycology. 49 (6): 672. doi:10.3109/13693786.2011.567303. ISSN 1460-2709. PMID 21410320.
  16. Bakhshizadeh, Mandana; Hashemian, Hamid Reza; Najafzadeh, Mohammad Javad; Dolatabadi, Somayeh; Zarrinfar, Hossein (1 July 2014). "First report of rhinosinusitis caused by Neoscytalidium dimidiatum in Iran". Journal of Medical Microbiology. 63 (Pt 7): 1017–1019. doi:10.1099/jmm.0.065292-0. ISSN 1473-5644. PMID 24850881.
  17. Yi, Run Hua; Lin, Qiao ling; Mo, Jun Jie; Wu, Feng Fa; Chen, Jing (8 April 2015). "Fruit internal brown rot caused by Neoscytalidium dimidiatum on pitahaya in Guangdong province, China". Australasian Plant Disease Notes. 10 (1): 13. doi:10.1007/s13314-015-0166-1. ISSN 1833-928X.
  18. Mohd, Masratul Hawa; Salleh, Baharuddin; Zakaria, Latiffah (1 December 2013). "Identification and Molecular Characterizations of Neoscytalidium dimidiatum Causing Stem Canker of Red-fleshed Dragon Fruit (Hylocereus polyrhizus) in Malaysia". Journal of Phytopathology. 161 (11–12): 841–849. doi:10.1111/jph.12146. ISSN 1439-0434.
  19. Rolshausen, P. E.; Akgül, D. S.; Perez, R.; Eskalen, A.; Gispert, C. (12 June 2013). "First Report of Wood Canker Caused by Neoscytalidium dimidiatum on Grapevine in California". Plant Disease. 97 (11): 1511. doi:10.1094/PDIS-04-13-0451-PDN. ISSN 0191-2917. PMID 30708472.
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