Neomycin/polymyxin B/hydrocortisone
Neomycin/polymyxin B/hydrocortisone, sold under the brand Otosporin among others, is a medication used to treat otitis externa (swimmer's ear) and certain eye disorders.[2][3] It consists of the antibiotics neomycin and polymyxin B, and the steroid hydrocortisone.[3] It is used as an ear drop or eye drop.[2][3]
Combination of | |
---|---|
Neomycin | Antibiotic |
Polymyxin B | Antibiotic |
Hydrocortisone | Glucocorticoid |
Clinical data | |
Trade names | Otosporin, Cortisporin, others |
AHFS/Drugs.com | FDA Professional Drug Information |
Pregnancy category |
|
Routes of administration | Ear drop, ear drop |
Legal status | |
Legal status |
|
Identifiers | |
KEGG |
The most common side effects include itchiness and a skin rash.[4] Other side effects may include dizziness, hives, anaphylaxis, hearing loss, and headache.[2][4] Safety in pregnancy and breastfeeding is unclear.[1] The antibiotics work by killing specific types of bacteria while the steroids work by decreasing inflammation.[5]
The combination was approved for medical use in the United States in 1964.[3] In the United Kingdom a 10 ml bottle costs the NHS about £7.45 as of 2019.[2] In the United States the wholesale cost of this amount is about US$50.[6] In 2017, it was the 304th most commonly prescribed medication in the United States, with more than one million prescriptions.[7]
History
Cortisporin was developed by Glaxo Wellcome and was approved by the Food and Drug Administration in 1975. In 1997, the rights were sold to Monarch Pharmaceuticals, a division of King Pharmaceuticals. In 2007, King sold it to JHP Pharmaceuticals. Par Pharmaceutical acquired JHP in 2014. In 2015, Endo International purchased Par.[8]
Cost
In David Lazarus' February 4, 2016 LA Times column, a pharmacist recalled a 10 milliliter vial of the drug selling for around $10 in the early 2010s. In 2015, the price was $100, and in 2016, it reportedly was selling for $195. A generic version is priced at $144.[8] The drug is owned by Dublin, Ireland-based Endo International.
Formulations
Generic name: neomycin sulfate, polymyxin B sulfate, and hydrocortisone
Dosage form: otic suspension (liquid with ear dropper)
Generic name: neomycin sulfate, polymyxin B sulfate, bacitracin zinc and hydrocortisone
Dosage form: Dermatological ointment, drops
References
- "Hydrocortisone / neomycin / polymyxin b otic Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
- British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1164. ISBN 9780857113382.
- "Neomycin, Polymyxin B, Hydrocortisone Ophthalmic Suspension - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 19 April 2019.
- "Hydrocortisone/neomycin/polymyxin b otic Side Effects in Detail". Drugs.com. Retrieved 19 April 2019.
- "DailyMed - neomycin sulfate, polymyxin b sulfate and hydrocortisone solution". dailymed.nlm.nih.gov. Retrieved 19 April 2019.
- "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
- "Neomycin; Polymyxin B; Hydrocortisone - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.
- Lazarus, David (2016-02-04). "Martin Shkreli isn't alone in ripping off patients with crazy drug prices". latimes.com. Retrieved 2016-02-05.