Naphazoline/pheniramine

Naphazoline/pheniramine, sold under the brand name Naphcon-A among others, is a combination eye drop used to help the symptoms of allergic conjunctivitis such as from hay fever.[1] It contains naphazoline and pheniramine.[1][2] It is used as an eye drop.[2] Use is not recommended for more than three days.[3]

Naphazoline/pheniramine
Combination of
PheniramineAntihistamine
Clinical data
Trade namesNaphcon-A, Opcon-A, Visine-A, others
AHFS/Drugs.comMultum Consumer Information
Pregnancy
category
  • US: C (Risk not ruled out)
    Routes of
    administration    		Eye drop
    Legal status
    Legal status

    Side effects may include allergic reactions, eye pain, and dilated pupils.[1][4][3] It is unclear if use in pregnancy is safe.[2] Nephazoline works by resulting in constriction of blood vessels thus decreasing redness well pheniramine works by blocking the effects of histamine to stop itching.[2]

    The combination was approved for medical use in the United States in 1994.[5][6][2] It is available over the counter.[5][6][1] In 2017, it was the 203rd most commonly prescribed medication in the United States, with more than two million prescriptions.[7][6]

    Medical use

    It is administered topically with one to two drops applied to the affected eye(s) up to four times daily.[1]

    Adverse effects
    • Pupils may become enlarged temporarily
    • Overuse may cause more redness
    • Those with heart disease, high blood pressure, narrow angle glaucoma or who have urination trouble are discouraged from using the product
    • It is recommended to remove contact lenses before use. Use with contact lenses can lead to reduced oxygenation of the underlying cornea
    • If infants or children accidentally ingest the drops, it may lead to coma and significant reduction in body temperature. If such ingestion occurs, immediately calling a poison control center is recommended[1]
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    References
    1. "Naphcon A- naphazoline hydrochloride and pheniramine maleate solution/ drops". DailyMed. 16 September 2019. Retrieved 10 August 2020.
    2. "Naphazoline and pheniramine ophthalmic Uses, Side Effects & Warnings". Drugs.com. Retrieved 19 April 2019.
    3. Kizior, Robert J.; Hodgson, Barbara B. (2014). Saunders Nursing Drug Handbook 2015 - E-Book. Elsevier Health Sciences. p. 163. ISBN 9780323280181.
    4. "Naphazoline/pheniramine ophthalmic Side Effects in Detail". Drugs.com. Retrieved 19 April 2019.
    5. "Naphcon-A: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 19 April 2020.
    6. "Naphazoline Hydrochloride; Pheniramine Maleate - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.
    7. "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
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